{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cordola Hsu AR"],"funding":["BLRD VA","NIDDK NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","CSRD VA"],"pagination":["e007297"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11978397"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(4)"],"pubmed_abstract":["<h4>Background</h4>Obesity is associated with an increased risk of heart failure (HF); however, how metabolic weight groups relate to HF risk, especially in postmenopausal women, has not been demonstrated.<h4>Methods</h4>We included 19 412 postmenopausal women ages 50 to 79 without cardiovascular disease from the Women's Health Initiative. Normal weight was defined as a body mass index ≥18.5 and <25 kg/m<sup>2</sup> and waist circumference <88 cm and overweight/obesity as a body mass index ≥25 kg/m<sup>2</sup> or waist circumference ≥88 cm. Metabolically healthy was based on <2 and unhealthy ≥2 cardiometabolic traits: triglycerides ≥150 mg/dL, systolic blood pressure ≥130 mm Hg or diastolic blood pressure ≥85 mm Hg or blood pressure medication, fasting glucose ≥100 mg/dL or diabetes medica"],"journal":["Circulation. Heart failure"],"pubmed_title":["Metabolically Healthy/Unhealthy Overweight/Obesity Associations With Incident Heart Failure in Postmenopausal Women: The Women's Health Initiative."],"pmcid":["PMC11978397"],"funding_grant_id":["R03 AI133172","I01 CX001737","P30 DK111024","U34 DK091958","I01 CX001025","I01 BX005831","U01 DK098246","HHSN268201600002C","HHSN268201600003C","R21 DK099716","HHSN268201600001C","HHSN268201600018C","HHSN268201600004C"],"pubmed_authors":["Ford L","Anton-Culver H","Thomson CA","Wactawski-Wende J","Ludlam S","Phillips LS","Prentice R","Peterson DV","Howard BV","Rossouw J","Stefanick ML","LaMonte MJ","Xie B","Wong ND","LaCroix A","Manson JE","Robinson J","Espeland M","Going SB","WHI Investigators","Limacher M","Cordola Hsu AR","Eaton CB","Jackson R","Geller N","Shumaker S","Brunner R","Garcia L","Kooperberg C","McGowan J","Anderson G","Kuller L"],"additional_accession":[]},"is_claimable":false,"name":"Metabolically Healthy/Unhealthy Overweight/Obesity Associations With Incident Heart Failure in Postmenopausal Women: The Women's Health Initiative.","description":"<h4>Background</h4>Obesity is associated with an increased risk of heart failure (HF); however, how metabolic weight groups relate to HF risk, especially in postmenopausal women, has not been demonstrated.<h4>Methods</h4>We included 19 412 postmenopausal women ages 50 to 79 without cardiovascular disease from the Women's Health Initiative. Normal weight was defined as a body mass index ≥18.5 and <25 kg/m<sup>2</sup> and waist circumference <88 cm and overweight/obesity as a body mass index ≥25 kg/m<sup>2</sup> or waist circumference ≥88 cm. Metabolically healthy was based on <2 and unhealthy ≥2 cardiometabolic traits: triglycerides ≥150 mg/dL, systolic blood pressure ≥130 mm Hg or diastolic blood pressure ≥85 mm Hg or blood pressure medication, fasting glucose ≥100 mg/dL or diabetes medica","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-07-05T03:04:50.637Z","creation":"2025-07-05T03:04:50.637Z"},"accession":"S-EPMC11978397","cross_references":{"pubmed":["33775111"],"doi":["10.1161/circheartfailure.120.007297","10.1161/CIRCHEARTFAILURE.120.007297"]}}