biostudies-literatureCordola Hsu ARBLRD VANIDDK NIH HHSNIAID NIH HHSNHLBI NIH HHSCSRD VAe007297https://www.ebi.ac.uk/biostudies/studies/S-EPMC11978397biostudies-literatureUnknown14(4)<h4>Background</h4>Obesity is associated with an increased risk of heart failure (HF); however, how metabolic weight groups relate to HF risk, especially in postmenopausal women, has not been demonstrated.<h4>Methods</h4>We included 19 412 postmenopausal women ages 50 to 79 without cardiovascular disease from the Women's Health Initiative. Normal weight was defined as a body mass index ≥18.5 and <25 kg/m² and waist circumference <88 cm and overweight/obesity as a body mass index ≥25 kg/m² or waist circumference ≥88 cm. Metabolically healthy was based on <2 and unhealthy ≥2 cardiometabolic traits: triglycerides ≥150 mg/dL, systolic blood pressure ≥130 mm Hg or diastolic blood pressure ≥85 mm Hg or blood pressure medication, fasting glucose ≥100 mg/dL or diabetes medicaCirculation. Heart failureMetabolically Healthy/Unhealthy Overweight/Obesity Associations With Incident Heart Failure in Postmenopausal Women: The Women's Health Initiative.PMC11978397R03 AI133172I01 CX001737P30 DK111024U34 DK091958I01 CX001025I01 BX005831U01 DK098246HHSN268201600002CHHSN268201600003CR21 DK099716HHSN268201600001CHHSN268201600018CHHSN268201600004CFord LAnton-Culver HThomson CAWactawski-Wende JLudlam SPhillips LSPrentice RPeterson DVHoward BVRossouw JStefanick MLLaMonte MJXie BWong NDLaCroix AManson JERobinson JEspeland MGoing SBWHI InvestigatorsLimacher MCordola Hsu AREaton CBJackson RGeller NShumaker SBrunner RGarcia LKooperberg CMcGowan JAnderson GKuller LfalseMetabolically Healthy/Unhealthy Overweight/Obesity Associations With Incident Heart Failure in Postmenopausal Women: The Women's Health Initiative.<h4>Background</h4>Obesity is associated with an increased risk of heart failure (HF); however, how metabolic weight groups relate to HF risk, especially in postmenopausal women, has not been demonstrated.<h4>Methods</h4>We included 19 412 postmenopausal women ages 50 to 79 without cardiovascular disease from the Women's Health Initiative. Normal weight was defined as a body mass index ≥18.5 and <25 kg/m² and waist circumference <88 cm and overweight/obesity as a body mass index ≥25 kg/m² or waist circumference ≥88 cm. Metabolically healthy was based on <2 and unhealthy ≥2 cardiometabolic traits: triglycerides ≥150 mg/dL, systolic blood pressure ≥130 mm Hg or diastolic blood pressure ≥85 mm Hg or blood pressure medication, fasting glucose ≥100 mg/dL or diabetes medica2021-01-01T00:00:00Z2021 Apr2025-07-05T03:04:50.637Z2025-07-05T03:04:50.637ZS-EPMC119783973377511110.1161/circheartfailure.120.00729710.1161/CIRCHEARTFAILURE.120.007297