biostudies-literatureLi WNWO-MiddelgrootVelux StiftungHorizon 2020Chinese Scholarship CouncilZonMwAGEM Talent and Development Grant2567-2580https://www.ebi.ac.uk/biostudies/studies/S-EPMC11979014biostudies-literatureUnknown47(2)Complex lipids, essential components in biological processes, exhibit conserved age-related changes that alter membrane properties and cellular functions and are implicated as biomarkers and contributors to longevity and age-related diseases. While physical activity alleviates age-related comorbidities and physical impairments, comprehensive exploration of the underlying biological mechanisms, particularly at the level of complex lipids, remains limited. However, clinical studies suggest that physical activity may counteract these age-related lipidomic changes, presenting a promising avenue for intervention. We performed lipidomic profiling of plasma from an extensively characterized cohort of young and aged individuals. Annotating 1446 unique lipid species across 24 lipid classes, we founGeroSciencePlasma triacylglycerol length and saturation level mark healthy aging groups in humans.PMC11979014911180061063Li WGrevendonk LGao AWVaz FMSalomons GSHoeks JJanssens GESchomakers BVSchrauwen Pvan Weeghel MHoutkooper RHfalsePlasma triacylglycerol length and saturation level mark healthy aging groups in humans.Complex lipids, essential components in biological processes, exhibit conserved age-related changes that alter membrane properties and cellular functions and are implicated as biomarkers and contributors to longevity and age-related diseases. While physical activity alleviates age-related comorbidities and physical impairments, comprehensive exploration of the underlying biological mechanisms, particularly at the level of complex lipids, remains limited. However, clinical studies suggest that physical activity may counteract these age-related lipidomic changes, presenting a promising avenue for intervention. We performed lipidomic profiling of plasma from an extensively characterized cohort of young and aged individuals. Annotating 1446 unique lipid species across 24 lipid classes, we foun2025-01-01T00:00:00Z2025 Apr2026-06-01T17:58:57.694Z2025-06-26T03:05:28.009ZS-EPMC119790143960199810.1007/s11357-024-01453-0