biostudies-literaturePerri GUKRI's Biotechnology and Biological Sciences Research CouncilMedical Research CouncilAGEing and Nutrient SensingUKRI’s Biotechnology and Biological Sciences Research CouncilBiotechnology and Biological Sciences Research Councilglae297https://www.ebi.ac.uk/biostudies/studies/S-EPMC11979094biostudies-literatureUnknown80(5)Biomarkers of aging serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which specific biomarkers are most appropriate for human intervention studies. This work aimed to address this need by establishing an expert consensus on biomarkers of aging for use in intervention studies via the Delphi method. A 3-round Delphi study was conducted using an online platform. In Round 1, expert panel members provided suggestions for candidate biomarkers of aging. In Rounds 2 and 3, they voted on 500 initial statements (yes/no) relating to 20 biomarkers of aging. Panel members could abstain from voting on biomarkers outside their expertise. Consensus was reached when there was ≥70% agreement on a statement/biomarker. Of the 460 international paThe journals of gerontology. Series A, Biological sciences and medical sciencesAn Expert Consensus Statement on Biomarkers of Aging for Use in Intervention Studies.PMC11979094BB/W018381/1Martins IJWilson TProkopidis KDotchin CLEspeland MAMattin LRClivaz-Duc Mde Lucia CEaglestone GTobin SWShannon OMPhillips SMKatsila TFerrucci LMoskalev ABaur JAJoshi PKSillanpaa EJain SPratt JNi Lochlainn MDiniz BSTeh RVila-Cha CJFisher JColloca GTan MMCDemetriades CSchomburg LMathers JCKhaiyat OAHassan-Smith ZMaier ABKorolchuk VIVorluni LWelch AAnand ARua-Alonso MScott DMerchant RAKemp GJCauli OLamming DWZhao TNeytchev OPhilippou ERattray NJWDi Gessa GMartin-Ruiz CPerri GHastings WJOwen CMWeber DGallegos JLArai YFrench CAntarianto RDWilson DMadeo FShyam SAgostinis-Sobrinho CHardiany NSGrammatopoulos DKElliott BTfalseAn Expert Consensus Statement on Biomarkers of Aging for Use in Intervention Studies.Biomarkers of aging serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which specific biomarkers are most appropriate for human intervention studies. This work aimed to address this need by establishing an expert consensus on biomarkers of aging for use in intervention studies via the Delphi method. A 3-round Delphi study was conducted using an online platform. In Round 1, expert panel members provided suggestions for candidate biomarkers of aging. In Rounds 2 and 3, they voted on 500 initial statements (yes/no) relating to 20 biomarkers of aging. Panel members could abstain from voting on biomarkers outside their expertise. Consensus was reached when there was ≥70% agreement on a statement/biomarker. Of the 460 international pa2025-01-01T00:00:00Z2025 Apr2025-07-06T03:04:29.735Z2025-07-06T03:04:29.735ZS-EPMC119790943970830010.1093/gerona/glae297