biostudies-literatureUnknown9(2)Fiorillo C<h4>Background</h4>Anastomotic leakage is a feared complication after colorectal resection. Recent advancements in surgical techniques, particularly the use of circular staplers, have aimed to improve postoperative outcomes. However, the optimal choice of circular stapler remains uncertain, with debate surrounding its impact on anastomotic leakage rates. The aim of this meta-analysis was to evaluate the impact of different circular stapler characteristics on anastomotic leakage occurrence after left colorectal resection.<h4>Methods</h4>A systematic review and meta-analysis using PubMed, Scopus, and Web of Science databases to identify studies on the correlation between circular staplers and anastomotic leakage occurrence were performed up to November 2023 (PROSPERO registration: CRD4202451BJS openzrae170https://www.ebi.ac.uk/biostudies/studies/S-EPMC11979101biostudies-literatureCircular staplers and anastomotic leakage in colorectal surgery: meta-analysis.PMC11979101Tondolo VQuero GLucinato CBiffoni BDe Sio DAlfieri SFiorillo CGambaro EfalseCircular staplers and anastomotic leakage in colorectal surgery: meta-analysis.<h4>Background</h4>Anastomotic leakage is a feared complication after colorectal resection. Recent advancements in surgical techniques, particularly the use of circular staplers, have aimed to improve postoperative outcomes. However, the optimal choice of circular stapler remains uncertain, with debate surrounding its impact on anastomotic leakage rates. The aim of this meta-analysis was to evaluate the impact of different circular stapler characteristics on anastomotic leakage occurrence after left colorectal resection.<h4>Methods</h4>A systematic review and meta-analysis using PubMed, Scopus, and Web of Science databases to identify studies on the correlation between circular staplers and anastomotic leakage occurrence were performed up to November 2023 (PROSPERO registration: CRD42024512025-01-01T00:00:00Z2025 Mar2025-07-10T03:08:20.829Z2025-07-10T03:08:20.829ZS-EPMC119791014020076210.1093/bjsopen/zrae170