{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Lv J"],"pubmed_abstract":["Polysaccharides, vital biological macromolecules ubiquitous in organisms, have garnered attention as potential therapeutic candidates for ulcerative colitis (UC). However, the therapeutic potential of <i>Rhodiola crenulata</i> polysaccharides (RCP) in UC remains largely unexplored. The RCP was prepared by boiling water extraction, 80% alcohol precipitation, membrane separation, and D101 macroporous resin purification. The monosaccharide composition of RCP (Mw = 67.848 kDa) includes mannose, rhamnose, glucuronic acid, galacturonic acid, glucose, galactose, and arabinose, with a molar ratio of 0.22:1:0.07:7.03:2.88:0.64:4.12. <i>In vivo</i> experiments have shown that RCP can improve DSS induced weight loss in UC mice, decrease disease activity index (DAI), alleviate histopathological change"],"journal":["Frontiers in pharmacology"],"pagination":["1519038"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11979201"],"repository":["biostudies-literature"],"pubmed_title":["&lt;i&gt;Rhodiola crenulata&lt;/i&gt; polysaccharide alleviates dextran sulfate sodium-induced ulcerative colitis in mice by repairing the intestinal barrier and regulating the intestinal microecology."],"pmcid":["PMC11979201"],"pubmed_authors":["Lv J","Cao L","Liu Z","Luo F","Xiao W","Su Z","Suo F","Wang Z","Kong X","Li M","Liu W"],"additional_accession":[]},"is_claimable":false,"name":"&lt;i&gt;Rhodiola crenulata&lt;/i&gt; polysaccharide alleviates dextran sulfate sodium-induced ulcerative colitis in mice by repairing the intestinal barrier and regulating the intestinal microecology.","description":"Polysaccharides, vital biological macromolecules ubiquitous in organisms, have garnered attention as potential therapeutic candidates for ulcerative colitis (UC). However, the therapeutic potential of <i>Rhodiola crenulata</i> polysaccharides (RCP) in UC remains largely unexplored. The RCP was prepared by boiling water extraction, 80% alcohol precipitation, membrane separation, and D101 macroporous resin purification. The monosaccharide composition of RCP (Mw = 67.848 kDa) includes mannose, rhamnose, glucuronic acid, galacturonic acid, glucose, galactose, and arabinose, with a molar ratio of 0.22:1:0.07:7.03:2.88:0.64:4.12. <i>In vivo</i> experiments have shown that RCP can improve DSS induced weight loss in UC mice, decrease disease activity index (DAI), alleviate histopathological change","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-07-05T03:04:30.19Z","creation":"2025-07-05T03:04:30.19Z"},"accession":"S-EPMC11979201","cross_references":{"pubmed":["40206066"],"doi":["10.3389/fphar.2025.1519038"]}}