biostudies-literatureUnknown25(1)Kruithof ESAccording to the cerebellar lateralization hypothesis of motivational direction, relative left-to-right dominant posterior cerebellar activity is associated with avoidance motivation and anxiety, whereas relative right-to-left dominant posterior cerebellar activity is associated with approach motivation and anger. The present study tested this hypothesis in avoidance-related behavior during rule learning combined with threat of shock. In a randomized double-blind sham-controlled between-subjects design, ninety healthy right-handed adult volunteers received either active (<i>n</i> = 45) or sham (<i>n</i> = 45) cerebellar left anodal-right cathodal transcranial direct current stimulation (tDCS) to the posterior cerebellum. During tDCS participants performed a gambling task with two changing International journal of clinical and health psychology : IJCHP100558https://www.ebi.ac.uk/biostudies/studies/S-EPMC11979461biostudies-literatureEffects of cerebellar transcranial direct current stimulation on reversal learning performance during threat of shock.PMC11979461Theodorakopoulou MEKruithof ESKlaus JSchutter DJLGWitteveen YKalligeri Skentzou EfalseEffects of cerebellar transcranial direct current stimulation on reversal learning performance during threat of shock.According to the cerebellar lateralization hypothesis of motivational direction, relative left-to-right dominant posterior cerebellar activity is associated with avoidance motivation and anxiety, whereas relative right-to-left dominant posterior cerebellar activity is associated with approach motivation and anger. The present study tested this hypothesis in avoidance-related behavior during rule learning combined with threat of shock. In a randomized double-blind sham-controlled between-subjects design, ninety healthy right-handed adult volunteers received either active (<i>n</i> = 45) or sham (<i>n</i> = 45) cerebellar left anodal-right cathodal transcranial direct current stimulation (tDCS) to the posterior cerebellum. During tDCS participants performed a gambling task with two changing 2025-01-01T00:00:00Z2025 Jan-Mar2026-05-29T14:47:37.241Z2026-04-08T05:08:50.66ZS-EPMC119794614020696010.1016/j.ijchp.2025.100558