{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["25(1)"],"submitter":["Cordero AIH"],"pubmed_abstract":["Background
The use of cannabis has been associated with both therapeutic and harmful effects. As with cigarette smoking, cannabis smoking may affect the epigenetic regulation (e.g., DNA methylation) of gene expression which could result in long term health effects. The study of DNA methylation in cannabis smoking has to date been restricted to young adults and there remains yet no evaluation of whether cannabis smoking cessation can reverse epigenetic disturbances. Here, we aimed to investigate the relationship between genome-wide DNA methylation and cannabis smoking.Methods
We used peripheral blood from a subset of older adults within the Canadian Cohort of Obstructive Lung Disease (CanCOLD) cohort (n = 93) to conduct an epigenome-wide DNA methylation analysis that identif"],"journal":["BMC pulmonary medicine"],"pagination":["168"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11980083"],"repository":["biostudies-literature"],"pubmed_title":["Cannabis smoking is associated with persistent epigenome-wide disruptions despite smoking cessation."],"pmcid":["PMC11980083"],"pubmed_authors":["Samet J","McNeil M","Hague C","Leipsic J","CanCOLD Collaborative Research Group","Marciniuk DD","Brouillard C","Labonte L","Doiron D","Fung C","Leung JM","Sin D","Yang J","Lo C","Fulton S","To T","Ambalavanan A","Tan WC","Pratt G","Li X","Machado L","Kobor MS","Li PZ","Tan W","Wigerius D","Un E","Hogg JC","Faroon F","Radivojevic O","Benedetti A","Johnson K","Audisho N","Jensen D","Osterling K","Gershon A","Zou C","Clemens R","Fortier Y","Vandemheen K","Cordero AIH","Cheng S","McClean P","Marciniuk D","Leuschen C","Zheng L","Walker B","Baril J","Yang CX","Road J","Coxson H","Song Z","Baran J","Chung S","Sadatsafavi M","Duan Q","FitzGerald J","Bourbeau J","Hernandez P","Kirby M","Mancino P","Bergeron A","Png A","Aaron S","O'Donnell D","Dumonceaux C","Sin DD","Baglole C","Maltais F","Hamid Q","Whelan K","MacIsaac JL","Chapman KR","Wang WT","O'Donnell DE","Puhan M","Comeau J","Chapman K"],"additional_accession":[]},"is_claimable":false,"name":"Cannabis smoking is associated with persistent epigenome-wide disruptions despite smoking cessation.","description":"Background
The use of cannabis has been associated with both therapeutic and harmful effects. As with cigarette smoking, cannabis smoking may affect the epigenetic regulation (e.g., DNA methylation) of gene expression which could result in long term health effects. The study of DNA methylation in cannabis smoking has to date been restricted to young adults and there remains yet no evaluation of whether cannabis smoking cessation can reverse epigenetic disturbances. Here, we aimed to investigate the relationship between genome-wide DNA methylation and cannabis smoking.Methods
We used peripheral blood from a subset of older adults within the Canadian Cohort of Obstructive Lung Disease (CanCOLD) cohort (n = 93) to conduct an epigenome-wide DNA methylation analysis that identif","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-06-01T21:09:52.657Z","creation":"2026-05-22T03:08:17.368Z"},"accession":"S-EPMC11980083","cross_references":{"pubmed":["40205553"],"doi":["10.1186/s12890-025-03634-9"]}}