{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dierckx L"],"funding":["Universiteit Antwerpen (UAntwerp)","Universiteit Antwerpen"],"pagination":["e0169624"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11980397"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["63(4)"],"pubmed_abstract":["<i>Streptococcus pneumoniae</i> serotype 23B, a non-vaccine serotype, has shown an increasing prevalence and penicillin non-susceptibility among carriage and invasive pneumococcal disease (IPD) isolates. Recently, a novel penicillin non-susceptible genotype has emerged, named 23B1. In the framework of the Belgian pneumococcal carriage study, we studied the prevalence of 23B<sub>0</sub>/23B1 among 586 23B strains (2016-2022) in 172 day care centers from 6- to 30-month-old children and among 130 pediatric 23B IPD isolates (2007-2021). Pneumococci were whole genome sequenced to determine the capsular polysaccharide genotype and sequence type (ST). Antimicrobial susceptibility testing determined penicillin and amoxicillin MICs, as well as resistance to co-trimoxazole and levofloxacin. 23B carr"],"journal":["Journal of clinical microbiology"],"pubmed_title":["Pneumococcal genotype 23B1 as a driver of increased 23B serotype carriage, penicillin non-susceptibility, and invasive disease in Belgium: a retrospective analysis."],"pmcid":["PMC11980397"],"funding_grant_id":["VAX-Idea Methusalem funds"],"pubmed_authors":["Cuypers L","Beutels P","Ekinci E","Maertens K","Dierckx L","Willen L","Rodriguez-Ruiz JP","Malhotra-Kumar S","van Heirstraeten L","Theeten H","Desmet S"],"additional_accession":[]},"is_claimable":false,"name":"Pneumococcal genotype 23B1 as a driver of increased 23B serotype carriage, penicillin non-susceptibility, and invasive disease in Belgium: a retrospective analysis.","description":"<i>Streptococcus pneumoniae</i> serotype 23B, a non-vaccine serotype, has shown an increasing prevalence and penicillin non-susceptibility among carriage and invasive pneumococcal disease (IPD) isolates. Recently, a novel penicillin non-susceptible genotype has emerged, named 23B1. In the framework of the Belgian pneumococcal carriage study, we studied the prevalence of 23B<sub>0</sub>/23B1 among 586 23B strains (2016-2022) in 172 day care centers from 6- to 30-month-old children and among 130 pediatric 23B IPD isolates (2007-2021). Pneumococci were whole genome sequenced to determine the capsular polysaccharide genotype and sequence type (ST). Antimicrobial susceptibility testing determined penicillin and amoxicillin MICs, as well as resistance to co-trimoxazole and levofloxacin. 23B carr","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-05T03:04:30.402Z","creation":"2025-07-05T03:04:30.402Z"},"accession":"S-EPMC11980397","cross_references":{"pubmed":["40071954"],"doi":["10.1128/jcm.01696-24"]}}