{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kohrt HE"],"funding":["NCI NIH HHS"],"pagination":["e284"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1198041"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(9)"],"pubmed_abstract":["<h4>Background</h4>While lymph node metastasis is among the strongest predictors of disease-free and overall survival for patients with breast cancer, the immunological nature of tumor-draining lymph nodes is often ignored, and may provide additional prognostic information on clinical outcome.<h4>Methods and findings</h4>We performed immunohistochemical analysis of 47 sentinel and 104 axillary (nonsentinel) nodes from 77 breast cancer patients with 5 y of follow-up to determine if alterations in CD4, CD8, and CD1a cell populations predict nodal metastasis or disease-free survival. Sentinel and axillary node CD4 and CD8 T cells were decreased in breast cancer patients compared to control nodes. CD1a dendritic cells were also diminished in sentinel and tumor-involved axillary nodes, but incr"],"journal":["PLoS medicine"],"pubmed_title":["Profile of immune cells in axillary lymph nodes predicts disease-free survival in breast cancer."],"pmcid":["PMC1198041"],"funding_grant_id":["R01 CA 090809","R01 CA090809"],"pubmed_authors":["Nowels K","Kohrt HE","Holmes S","Lee PP","Johnson D","Nouri N"],"additional_accession":[]},"is_claimable":false,"name":"Profile of immune cells in axillary lymph nodes predicts disease-free survival in breast cancer.","description":"<h4>Background</h4>While lymph node metastasis is among the strongest predictors of disease-free and overall survival for patients with breast cancer, the immunological nature of tumor-draining lymph nodes is often ignored, and may provide additional prognostic information on clinical outcome.<h4>Methods and findings</h4>We performed immunohistochemical analysis of 47 sentinel and 104 axillary (nonsentinel) nodes from 77 breast cancer patients with 5 y of follow-up to determine if alterations in CD4, CD8, and CD1a cell populations predict nodal metastasis or disease-free survival. Sentinel and axillary node CD4 and CD8 T cells were decreased in breast cancer patients compared to control nodes. CD1a dendritic cells were also diminished in sentinel and tumor-involved axillary nodes, but incr","dates":{"release":"2005-01-01T00:00:00Z","publication":"2005 Sep","modification":"2025-04-05T12:49:18.785Z","creation":"2019-03-27T01:09:19Z"},"accession":"S-EPMC1198041","cross_references":{"pubmed":["16124834"],"doi":["10.1371/journal.pmed.0020284"]}}