{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Ivanovska A"],"pubmed_abstract":["<h4>Objective</h4>Osteoarthritis (OA) is a widespread and debilitating joint disease characterized by synovial inflammation, cartilage degeneration, and chronic joint pain. Mesenchymal stromal cells (MSCs) have shown therapeutic efficacy for many diseases with a strong inflammatory profile, including OA. However, the disease-specific mechanisms of action underpinning the effects of post-local MSC delivery remain unaddressed. In this study, we aimed to characterize the disease-induced profile of MSCs following exposure to the <i>in vivo</i> osteoarthritis environment.<h4>Methods</h4>Murine syngeneic GFP + bone marrow-derived MSCs (BM-MSCs) were delivered <i>via</i> intra-articular injection in a mouse collagenase-induced osteoarthritis (CIOA) model (n = 8). BM-MSCs were retrieved by cell so"],"journal":["Frontiers in cell and developmental biology"],"pagination":["1521437"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11980424"],"repository":["biostudies-literature"],"pubmed_title":["Identification of disease-stage therapeutic responses of mesenchymal stromal cells retrieved from murine osteoarthritic joints."],"pmcid":["PMC11980424"],"pubmed_authors":["Burke A","Morris DW","English K","McLoughlin S","Mukeria E","Reilly J","Ritter T","Raman S","O'Brien A","Johnstone B","Hennessy C","Dooley C","Ryan AE","Kamath R","Mancuso P","Murphy JM","Shaw G","Riet DV","Barry F","Ivanovska A","Levesque MC","Hawthorne I"],"additional_accession":[]},"is_claimable":false,"name":"Identification of disease-stage therapeutic responses of mesenchymal stromal cells retrieved from murine osteoarthritic joints.","description":"<h4>Objective</h4>Osteoarthritis (OA) is a widespread and debilitating joint disease characterized by synovial inflammation, cartilage degeneration, and chronic joint pain. Mesenchymal stromal cells (MSCs) have shown therapeutic efficacy for many diseases with a strong inflammatory profile, including OA. However, the disease-specific mechanisms of action underpinning the effects of post-local MSC delivery remain unaddressed. In this study, we aimed to characterize the disease-induced profile of MSCs following exposure to the <i>in vivo</i> osteoarthritis environment.<h4>Methods</h4>Murine syngeneic GFP + bone marrow-derived MSCs (BM-MSCs) were delivered <i>via</i> intra-articular injection in a mouse collagenase-induced osteoarthritis (CIOA) model (n = 8). BM-MSCs were retrieved by cell so","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-07-07T03:09:01.894Z","creation":"2025-07-07T03:09:01.894Z"},"accession":"S-EPMC11980424","cross_references":{"pubmed":["40206403"],"doi":["10.3389/fcell.2025.1521437"]}}