{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Martino C"],"funding":["Emil Aaltosen Säätiö (Emil Aaltonen Foundation)","IBM | IBM Research","NIEHS NIH HHS","NHLBI NIH HHS","NIHR | NIHR Cambridge Biomedical Research Centre (NIHR Cambridge BRC)","French National Research Agency","Alfred Benzon Foundation","National Science Foundation (NSF)","Alfred Benzon Foundation (The Alfred Benzon Foundation)","Academy of Finland","Emerald Foundation","NCCIH NIH HHS","Emil Aaltosen Säätiö","UC | University of California, San Diego (UCSD)","Health Data Research UK (HDR UK)","UC | University of California, San Diego","National Science Foundation","Novo Nordisk Foundation","British Heart Foundation","HHS | National Institutes of Health (NIH)","NIAID NIH HHS","UC San Diego Center for Microbiome Innovation","HHS | National Institutes of Health","Sydäntutkimussäätiö","ANID Becas Chile Doctorado","Health Data Research UK","Munz Chair of Cardiovascular Prediction and Prevention","NIDDK NIH HHS","Sydäntutkimussäätiö (Finnish Foundation for Cardiovascular Research)","Union's Horizon Europe Research and Innovation 459 Actions","NCI NIH HHS","Union's Horizon Europe Research and Innovation 459 Actions","NIHR | NIHR Cambridge Biomedical Research Centre","Wellcome Trust","NIGMS NIH HHS"],"pagination":["e0401524"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11980591"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(4)"],"pubmed_abstract":["The gastrointestinal (GI) tract is a site of replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and GI symptoms are often reported by patients. SARS-CoV-2 cell entry depends upon heparan sulfate (HS) proteoglycans, which commensal bacteria that bathe the human mucosa are known to modify. To explore human gut HS-modifying bacterial abundances and how their presence may impact SARS-CoV-2 infection, we developed a task-based analysis of proteoglycan degradation on large-scale shotgun metagenomic data. We observed that gut bacteria with high predicted catabolic capacity for HS differ by age and sex, factors associated with coronavirus disease 2019 (COVID-19) severity, and directly by disease severity during/after infection, but do not vary between subjects with COVID-1"],"journal":["mBio"],"pubmed_title":["SARS-CoV-2 infectivity can be modulated through bacterial grooming of the glycocalyx."],"pmcid":["PMC11980591"],"funding_grant_id":["U19 AI116497","N/A","R01ES027595","UH2AI153029","3022","1P30DK120515","RG/18/13/33946","R01 GM069811","UM1-CA164917","321351 and 354447","BRC-1215-20014","R01-CA077398","RG/13/13/30194","ANR-20-CE44-0005","UH2 AI153029","2031989","P30-CA023100","P30 CA023100","R01 CA077398","R35GM119850","AI Horizons Network","UM1 CA164917","U01-CA199277","P01 HL131474","NNF20SA0066621","P30 CA033572","R01 ES027595","101046041","P30-CA033572","335525","U01 CA199277","R00RG2503","R01GM069811","2018-72190270","2038509","ANR-17-CE11-0014","DP1 AT010885","P30 DK120515","R35 GM119850","1DP1AT010885","321356"],"pubmed_authors":["McDonald D","Zaramela LS","Cooper R","Esko JD","Martino C","Riva A","Liang C","Inouye M","Spielfogel ES","Lewis NE","Marotz CA","Sweeney DA","Niiranen T","Taylor B","Haiminen N","Sorrentino JT","Martinez ME","Kim H-C","Paulus MP","Jain M","Kosciolek T","Broedlow CA","Berteau O","Anderson CAM","Hasty J","Belda-Ferre P","Schifanella L","Lacey JV","Salomaa V","Lai A","Das P","Carlin AF","Cheng S","Garretson AF","Klatt NR","Vazquez-Baeza Y","Basting C","Swafford AD","Soualmia F","Salido RA","Clausen TM","Estaki M","Benjdia A","Ali F","Victor TA","Savage KE","Kellman BP","Parida L","Armingol E","Covizzi A","Song SJ","Gilbert JA","Kuplicki R","Knight R","Huang S","Allard SM","Benbow JL","Zhang Y","Jousilahti P","Sandoval DR","Zengler K","Havulinna AS","Zhu Q","Clark AE","Wandro S"],"additional_accession":[]},"is_claimable":false,"name":"SARS-CoV-2 infectivity can be modulated through bacterial grooming of the glycocalyx.","description":"The gastrointestinal (GI) tract is a site of replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and GI symptoms are often reported by patients. SARS-CoV-2 cell entry depends upon heparan sulfate (HS) proteoglycans, which commensal bacteria that bathe the human mucosa are known to modify. To explore human gut HS-modifying bacterial abundances and how their presence may impact SARS-CoV-2 infection, we developed a task-based analysis of proteoglycan degradation on large-scale shotgun metagenomic data. We observed that gut bacteria with high predicted catabolic capacity for HS differ by age and sex, factors associated with coronavirus disease 2019 (COVID-19) severity, and directly by disease severity during/after infection, but do not vary between subjects with COVID-1","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-06-02T19:08:59.459Z","creation":"2025-07-13T03:04:39.863Z"},"accession":"S-EPMC11980591","cross_references":{"pubmed":["39998226"],"doi":["10.1128/mbio.04015-24"]}}