biostudies-literatureTinh NQBộ Giáo dục và Ðào tạo11243-11256https://www.ebi.ac.uk/biostudies/studies/S-EPMC11980596biostudies-literatureUnknown15(14)Plant essential oils can function as effective antibacterial and anticancer agents, but their low solubility and hydrophobic nature limit their practical applications. In this study, we report the preparation of nanoemulsions of <i>Elsholtzia kachinensis</i> and <i>Elsholtzia ciliata via</i> ultrasonic homogenization and the characterization of their antibacterial and anticancer activities for the first time. The product characteristics were evaluated based on turbidity, droplet size, polydispersion index, zeta potential and electrophoretic mobility. The activities were evaluated based on their ability to inhibit the growth of bacteria and HepG2 cancer cells. The <i>Elsholtzia kachinensis</i> and <i>Elsholtzia ciliata</i> nanoemulsions exhibited good stabilities, narrow size distributions RSC advancesPreparation of nanoemulsions from &lt;i&gt;Elsholtzia kachinensis&lt;/i&gt; and &lt;i&gt;Elsholtzia ciliata&lt;/i&gt; essential oils &lt;i&gt;via&lt;/i&gt; ultrasonic homogenization and their antibacterial and anticancer activities.PMC11980596B2024-TNA-14Thi Thuy NTinh NQDieu Thuy PPhu Hung NHoa Mi NThi Tam KQuynh Nhung BTVan Thu NNgoc Huyen PVan Thanh DfalsePreparation of nanoemulsions from &lt;i&gt;Elsholtzia kachinensis&lt;/i&gt; and &lt;i&gt;Elsholtzia ciliata&lt;/i&gt; essential oils &lt;i&gt;via&lt;/i&gt; ultrasonic homogenization and their antibacterial and anticancer activities.Plant essential oils can function as effective antibacterial and anticancer agents, but their low solubility and hydrophobic nature limit their practical applications. In this study, we report the preparation of nanoemulsions of <i>Elsholtzia kachinensis</i> and <i>Elsholtzia ciliata via</i> ultrasonic homogenization and the characterization of their antibacterial and anticancer activities for the first time. The product characteristics were evaluated based on turbidity, droplet size, polydispersion index, zeta potential and electrophoretic mobility. The activities were evaluated based on their ability to inhibit the growth of bacteria and HepG2 cancer cells. The <i>Elsholtzia kachinensis</i> and <i>Elsholtzia ciliata</i> nanoemulsions exhibited good stabilities, narrow size distributions 2025-01-01T00:00:00Z2025 Apr2025-07-13T03:04:38.161Z2025-07-13T03:04:38.161ZS-EPMC119805964020635610.1039/d5ra00386e