{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tanaka M"],"funding":["Japan Society for the Promotion of Science"],"pagination":["sfaf056"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11980977"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(4)"],"pubmed_abstract":["<h4>Background</h4>Fatty acid-binding protein 4 (FABP4) is an adipokine secreted from adipocytes and macrophages and is also expressed in injured, but not normal, glomerular endothelial cells. Elevated levels of urinary FABP4 (U-FABP4) have been reported to be associated with glomerular damage and increased proteinuria.<h4>Methods</h4>The associations of levels of U-FABP4 at baseline with future events including renal dysfunction defined by a 30% decline in estimated glomerular filtration rate (eGFR) and all-cause death were investigated in 660 patients with diabetes (type 1/2, 57/603).<h4>Results</h4>During a follow-up period (median: 62 months), 90 patients (13.6%) developed renal dysfunction, and 66 patients (10.0%) died (median follow-up period 65 months). Kaplan-Meier survival curves "],"journal":["Clinical kidney journal"],"pubmed_title":["Elevated urinary fatty acid-binding protein 4 level predicts future renal dysfunction and poor prognosis in Japanese patients with diabetes: a longitudinal cohort study."],"pmcid":["PMC11980977"],"funding_grant_id":["23K07993","23K07681","22K08313"],"pubmed_authors":["Kamei N","Suzuki T","Akiyama Y","Endo K","Furuhashi M","Murakoshi M","Aida H","Kubota M","Sato T","Ishiwata E","Sanuki M","Suzuki Y","Nakata K","Gohda T","Kawaharata W","Tanaka M"],"additional_accession":[]},"is_claimable":false,"name":"Elevated urinary fatty acid-binding protein 4 level predicts future renal dysfunction and poor prognosis in Japanese patients with diabetes: a longitudinal cohort study.","description":"<h4>Background</h4>Fatty acid-binding protein 4 (FABP4) is an adipokine secreted from adipocytes and macrophages and is also expressed in injured, but not normal, glomerular endothelial cells. Elevated levels of urinary FABP4 (U-FABP4) have been reported to be associated with glomerular damage and increased proteinuria.<h4>Methods</h4>The associations of levels of U-FABP4 at baseline with future events including renal dysfunction defined by a 30% decline in estimated glomerular filtration rate (eGFR) and all-cause death were investigated in 660 patients with diabetes (type 1/2, 57/603).<h4>Results</h4>During a follow-up period (median: 62 months), 90 patients (13.6%) developed renal dysfunction, and 66 patients (10.0%) died (median follow-up period 65 months). Kaplan-Meier survival curves ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-10T03:08:04.791Z","creation":"2025-07-10T03:08:04.791Z"},"accession":"S-EPMC11980977","cross_references":{"pubmed":["40207099"],"doi":["10.1093/ckj/sfaf056"]}}