biostudies-literatureTanaka MJapan Society for the Promotion of Sciencesfaf056https://www.ebi.ac.uk/biostudies/studies/S-EPMC11980977biostudies-literatureUnknown18(4)<h4>Background</h4>Fatty acid-binding protein 4 (FABP4) is an adipokine secreted from adipocytes and macrophages and is also expressed in injured, but not normal, glomerular endothelial cells. Elevated levels of urinary FABP4 (U-FABP4) have been reported to be associated with glomerular damage and increased proteinuria.<h4>Methods</h4>The associations of levels of U-FABP4 at baseline with future events including renal dysfunction defined by a 30% decline in estimated glomerular filtration rate (eGFR) and all-cause death were investigated in 660 patients with diabetes (type 1/2, 57/603).<h4>Results</h4>During a follow-up period (median: 62 months), 90 patients (13.6%) developed renal dysfunction, and 66 patients (10.0%) died (median follow-up period 65 months). Kaplan-Meier survival curves Clinical kidney journalElevated urinary fatty acid-binding protein 4 level predicts future renal dysfunction and poor prognosis in Japanese patients with diabetes: a longitudinal cohort study.PMC1198097723K0799323K0768122K08313Kamei NSuzuki TAkiyama YEndo KFuruhashi MMurakoshi MAida HKubota MSato TIshiwata ESanuki MSuzuki YNakata KGohda TKawaharata WTanaka MfalseElevated urinary fatty acid-binding protein 4 level predicts future renal dysfunction and poor prognosis in Japanese patients with diabetes: a longitudinal cohort study.<h4>Background</h4>Fatty acid-binding protein 4 (FABP4) is an adipokine secreted from adipocytes and macrophages and is also expressed in injured, but not normal, glomerular endothelial cells. Elevated levels of urinary FABP4 (U-FABP4) have been reported to be associated with glomerular damage and increased proteinuria.<h4>Methods</h4>The associations of levels of U-FABP4 at baseline with future events including renal dysfunction defined by a 30% decline in estimated glomerular filtration rate (eGFR) and all-cause death were investigated in 660 patients with diabetes (type 1/2, 57/603).<h4>Results</h4>During a follow-up period (median: 62 months), 90 patients (13.6%) developed renal dysfunction, and 66 patients (10.0%) died (median follow-up period 65 months). Kaplan-Meier survival curves 2025-01-01T00:00:00Z2025 Apr2025-07-10T03:08:04.791Z2025-07-10T03:08:04.791ZS-EPMC119809774020709910.1093/ckj/sfaf056