{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(3)"],"submitter":["He S"],"pubmed_abstract":["<h4>Background</h4>Pleuropulmonary blastoma (PPB) is a rare and highly aggressive malignant tumor of the lung or pleura, primarily affecting children and closely associated with <i>DICER1</i> gene mutations. Patients with type II and III PPB are prone to distant metastasis, with the central nervous system (CNS) being the most common site of metastasis, leading to a poor prognosis.<h4>Case description</h4>This article provides a detailed account of the clinical manifestations, diagnostic processes, treatment plans, and follow-up outcomes of three children diagnosed with PPB accompanied by brain metastasis. Through the collaborative diagnosis and treatment by a multidisciplinary team, all three patients are currently in remission. As part of the diagnostic and treatment process, genetic test"],"journal":["Translational pediatrics"],"pagination":["480-486"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11983002"],"repository":["biostudies-literature"],"pubmed_title":["Brain metastasis of pleuropulmonary blastoma: case reports."],"pmcid":["PMC11983002"],"pubmed_authors":["He S","Liu Z","Zhao W","Ma X","Duan C","Fu L","Yu T","Ge M","Cui C","Su Y"],"additional_accession":[]},"is_claimable":false,"name":"Brain metastasis of pleuropulmonary blastoma: case reports.","description":"<h4>Background</h4>Pleuropulmonary blastoma (PPB) is a rare and highly aggressive malignant tumor of the lung or pleura, primarily affecting children and closely associated with <i>DICER1</i> gene mutations. Patients with type II and III PPB are prone to distant metastasis, with the central nervous system (CNS) being the most common site of metastasis, leading to a poor prognosis.<h4>Case description</h4>This article provides a detailed account of the clinical manifestations, diagnostic processes, treatment plans, and follow-up outcomes of three children diagnosed with PPB accompanied by brain metastasis. Through the collaborative diagnosis and treatment by a multidisciplinary team, all three patients are currently in remission. As part of the diagnostic and treatment process, genetic test","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-07-08T03:10:17.885Z","creation":"2025-07-08T03:10:17.885Z"},"accession":"S-EPMC11983002","cross_references":{"pubmed":["40225067"],"doi":["10.21037/tp-24-341"]}}