biostudies-literatureUnknown14(3)He S<h4>Background</h4>Pleuropulmonary blastoma (PPB) is a rare and highly aggressive malignant tumor of the lung or pleura, primarily affecting children and closely associated with <i>DICER1</i> gene mutations. Patients with type II and III PPB are prone to distant metastasis, with the central nervous system (CNS) being the most common site of metastasis, leading to a poor prognosis.<h4>Case description</h4>This article provides a detailed account of the clinical manifestations, diagnostic processes, treatment plans, and follow-up outcomes of three children diagnosed with PPB accompanied by brain metastasis. Through the collaborative diagnosis and treatment by a multidisciplinary team, all three patients are currently in remission. As part of the diagnostic and treatment process, genetic testTranslational pediatrics480-486https://www.ebi.ac.uk/biostudies/studies/S-EPMC11983002biostudies-literatureBrain metastasis of pleuropulmonary blastoma: case reports.PMC11983002He SLiu ZZhao WMa XDuan CFu LYu TGe MCui CSu YfalseBrain metastasis of pleuropulmonary blastoma: case reports.<h4>Background</h4>Pleuropulmonary blastoma (PPB) is a rare and highly aggressive malignant tumor of the lung or pleura, primarily affecting children and closely associated with <i>DICER1</i> gene mutations. Patients with type II and III PPB are prone to distant metastasis, with the central nervous system (CNS) being the most common site of metastasis, leading to a poor prognosis.<h4>Case description</h4>This article provides a detailed account of the clinical manifestations, diagnostic processes, treatment plans, and follow-up outcomes of three children diagnosed with PPB accompanied by brain metastasis. Through the collaborative diagnosis and treatment by a multidisciplinary team, all three patients are currently in remission. As part of the diagnostic and treatment process, genetic test2025-01-01T00:00:00Z2025 Mar2025-07-08T03:10:17.885Z2025-07-08T03:10:17.885ZS-EPMC119830024022506710.21037/tp-24-341