biostudies-literatureUnknown21(1)Aggarwal RChalmers University of TechnologyThis research aims to address the data gaps in freshwater ecotoxicological characterization factors (CFs) for per- and polyfluoroalkyl substances (PFASs). These CFs are essential for incorporating the ecotoxicity impacts of PFAS emissions into life cycle assessments (LCAs). This study has three primary objectives: first, to calculate a comprehensive set of experimental aquatic ecotoxicity CFs for PFASs utilizing the USEtox model (version 2.13); second, to compare these newly derived CFs with those generated using the PFAS-adapted USEtox model; and finally, to test the hypothesis concerning a potential correlation between CFs and effect factors (EFs) with the number of perfluorinated carbons in PFASs. In this study, 367 PFASs were selected from the CompTox Chemicals Dashboard PFAS suspect lIntegrated environmental assessment and management208-219https://www.ebi.ac.uk/biostudies/studies/S-EPMC11984296biostudies-literatureFreshwater ecotoxicity characterization factors for PFASs.PMC11984296Aggarwal RfalseFreshwater ecotoxicity characterization factors for PFASs.This research aims to address the data gaps in freshwater ecotoxicological characterization factors (CFs) for per- and polyfluoroalkyl substances (PFASs). These CFs are essential for incorporating the ecotoxicity impacts of PFAS emissions into life cycle assessments (LCAs). This study has three primary objectives: first, to calculate a comprehensive set of experimental aquatic ecotoxicity CFs for PFASs utilizing the USEtox model (version 2.13); second, to compare these newly derived CFs with those generated using the PFAS-adapted USEtox model; and finally, to test the hypothesis concerning a potential correlation between CFs and effect factors (EFs) with the number of perfluorinated carbons in PFASs. In this study, 367 PFASs were selected from the CompTox Chemicals Dashboard PFAS suspect l2025-01-01T00:00:00Z2025 Jan2025-07-07T03:08:16.853Z2025-07-07T03:08:16.853ZS-EPMC119842963987921410.1093/inteam/vjae013