{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Srinivasan S"],"funding":["BLRD VA","NCATS NIH HHS","NIAID NIH HHS","NCI NIH HHS","National Institutes of Health","VA","U.S. Department of Veterans Affairs","NIH HHS"],"pagination":["e14461"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11984669"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(4)"],"pubmed_abstract":["Aging is tightly associated with reduced immune protection but increased risk of autoimmunity and inflammatory conditions. Regulatory T cells are one of the key cells to maintaining immune homeostasis. The age-dependent changes in CD4<sup>+</sup>Foxp3<sup>+</sup> regulatory T cells (Tregs) have been well documented. However, the nonredundant Foxp3<sup>-</sup>CD8<sup>+</sup> Tregs were never examined in the context of aging. This study first established clear distinctions between phenotypically overlapping CD8<sup>+</sup> Tregs and virtual memory T cells. Then, we elucidated the dynamics of CD8<sup>+</sup> Tregs across the lifespan in mice and further extended our investigation to human peripheral blood mononuclear cells (PBMCs). In mice, we discovered a bi-phasic dynamic shift in the frequ"],"journal":["Aging cell"],"pubmed_title":["Age-Dependent Bi-Phasic Dynamics of Ly49&lt;sup&gt;+&lt;/sup&gt;CD8&lt;sup&gt;+&lt;/sup&gt; Regulatory T Cell Population."],"pmcid":["PMC11984669"],"funding_grant_id":["R01 CA288321","AI125701","R01 AI125701","P30 CA054174","I01BX005955","UL1 TR002645","AI177345","CA288321","I01 BX005955","R01 AI177345"],"pubmed_authors":["Fan KK","Segura C","Ma C","Mukherjee N","Huang G","Mishra S","Srinivasan S","Zhang N","Im J","Rao M","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Age-Dependent Bi-Phasic Dynamics of Ly49&lt;sup&gt;+&lt;/sup&gt;CD8&lt;sup&gt;+&lt;/sup&gt; Regulatory T Cell Population.","description":"Aging is tightly associated with reduced immune protection but increased risk of autoimmunity and inflammatory conditions. Regulatory T cells are one of the key cells to maintaining immune homeostasis. The age-dependent changes in CD4<sup>+</sup>Foxp3<sup>+</sup> regulatory T cells (Tregs) have been well documented. However, the nonredundant Foxp3<sup>-</sup>CD8<sup>+</sup> Tregs were never examined in the context of aging. This study first established clear distinctions between phenotypically overlapping CD8<sup>+</sup> Tregs and virtual memory T cells. Then, we elucidated the dynamics of CD8<sup>+</sup> Tregs across the lifespan in mice and further extended our investigation to human peripheral blood mononuclear cells (PBMCs). In mice, we discovered a bi-phasic dynamic shift in the frequ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-06-01T13:07:21.772Z","creation":"2026-04-08T12:50:02.655Z"},"accession":"S-EPMC11984669","cross_references":{"pubmed":["39696807"],"doi":["10.1111/acel.14461"]}}