{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Green EH"],"funding":["Veterans Administration Medical Center","BLRD VA","NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","National Cancer Institute","NCI NIH HHS","Veterans Administration Medical Center, Yale School of Medicine"],"pagination":["51-65"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11985286"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["266(1)"],"pubmed_abstract":["Colorectal cancer (CRC) is responsible for over 900,000 annual deaths worldwide. Emerging evidence supports pro-carcinogenic bacteria in the colonic microbiome are at least promotional in CRC development and may be causal. We previously showed toxigenic C. difficile from human CRC-associated bacterial biofilms accelerates tumorigenesis in Apc<sup>Min/+</sup> mice, both in specific pathogen-free mice and in gnotobiotic mice colonized with a defined consortium of bacteria. To further understand host-microbe interactions during colonic tumorigenesis, we combined single-cell RNA-sequencing (scRNA-seq), spatial transcriptomics, and immunofluorescence to define the molecular spatial organization of colonic dysplasia in our consortium model with or without C. difficile. Our data show a striking b"],"journal":["The Journal of pathology"],"pubmed_title":["Multiomic spatial atlas shows deleted in malignant brain tumors 1 (DMBT1) glycoprotein is lost in colonic dysplasia."],"pmcid":["PMC11985286"],"funding_grant_id":["BX005699","IK2 BX005699","P30DK058404","P30CA068485","P30 DK058404","BX002943","U54 CA274367","I01 BX002943","F31 CA294983","R00 CA230192","P50CA236733","P30 CA068485","P50 CA236733","R00CA230192","R35 CA197570"],"pubmed_authors":["Sears CL","Ding H","Coffey RJ","Rutherford ME","Lunnemann HM","Liu Q","Drewes JL","Liu X","Washington MK","Kaur H","Heiser CN","Lau KS","Green EH","Shrubsole MJ","Lacy DB","Kotrannavar SR","Markham NO","Simmons AJ"],"additional_accession":[]},"is_claimable":false,"name":"Multiomic spatial atlas shows deleted in malignant brain tumors 1 (DMBT1) glycoprotein is lost in colonic dysplasia.","description":"Colorectal cancer (CRC) is responsible for over 900,000 annual deaths worldwide. Emerging evidence supports pro-carcinogenic bacteria in the colonic microbiome are at least promotional in CRC development and may be causal. We previously showed toxigenic C. difficile from human CRC-associated bacterial biofilms accelerates tumorigenesis in Apc<sup>Min/+</sup> mice, both in specific pathogen-free mice and in gnotobiotic mice colonized with a defined consortium of bacteria. To further understand host-microbe interactions during colonic tumorigenesis, we combined single-cell RNA-sequencing (scRNA-seq), spatial transcriptomics, and immunofluorescence to define the molecular spatial organization of colonic dysplasia in our consortium model with or without C. difficile. Our data show a striking b","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-01T23:04:45.502Z","creation":"2025-07-05T03:04:35.496Z"},"accession":"S-EPMC11985286","cross_references":{"pubmed":["40026233"],"doi":["10.1002/path.6406"]}}