{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Meagher NS"],"funding":["Peter MacCallum Foundation","National Health and Medical Research Council"],"pagination":["9-25"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11985703"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["266(1)"],"pubmed_abstract":["Mucinous ovarian carcinoma (MOC) is a rare histotype of epithelial ovarian cancer. Its origins are obscure: while many mucinous tumours in the ovary are metastases from the gastrointestinal tract, MOC can occur as an ovarian primary; however, the cell of origin is not well established. In this review we summarise the pathological, epidemiological, and molecular evidence for the cellular origins of MOC. We propose a model for the origins of the various tumours of the ovary with mucinous differentiation. We distinguish Müllerian from gastrointestinal-type mucinous differentiation. A small proportion of the latter arise from teratoma and a distinct terminology has been proposed. Other gastrointestinal mucinous tumours are associated with Brenner tumours and arise from their associated benign "],"journal":["The Journal of pathology"],"pubmed_title":["Cellular origins of mucinous ovarian carcinoma."],"pmcid":["PMC11985703"],"funding_grant_id":["GNT1173346","GNT2009840","GNT2002943"],"pubmed_authors":["Kobel M","Karnezis AN","Anglesio MS","Gorringe KL","Webb PM","Gayther SA","Meagher NS","Ramus SJ","Pharoah PP","Talhouk A","Berchuck A"],"additional_accession":[]},"is_claimable":false,"name":"Cellular origins of mucinous ovarian carcinoma.","description":"Mucinous ovarian carcinoma (MOC) is a rare histotype of epithelial ovarian cancer. Its origins are obscure: while many mucinous tumours in the ovary are metastases from the gastrointestinal tract, MOC can occur as an ovarian primary; however, the cell of origin is not well established. In this review we summarise the pathological, epidemiological, and molecular evidence for the cellular origins of MOC. We propose a model for the origins of the various tumours of the ovary with mucinous differentiation. We distinguish Müllerian from gastrointestinal-type mucinous differentiation. A small proportion of the latter arise from teratoma and a distinct terminology has been proposed. Other gastrointestinal mucinous tumours are associated with Brenner tumours and arise from their associated benign ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-01T13:10:07.8Z","creation":"2025-07-12T03:04:26.336Z"},"accession":"S-EPMC11985703","cross_references":{"pubmed":["40028669"],"doi":["10.1002/path.6407"]}}