{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2025"],"submitter":["Liu MC"],"pubmed_abstract":["<b>Background:</b> Reduction of <i>Faecalibacterium prausnitzii</i> abundance is related to inflammatory bowel diseases (IBDs), and supplement of it exists protective effects. <b>Aim:</b> This study aimed to establish a <i>F. prausnitzii</i>-colonized mouse model and investigate that the presence of <i>F. prausnitzii</i> in the gut can ameliorate the severity of dextran sulfate sodium (DSS)-induced colitis. <b>Methods:</b> A <i>F. prausnitzii</i> (ATCC 27768) strain was maintained on the PS-BHI agar plates and manipulated in a strictly anaerobic chamber. A <i>F. prausnitzii</i>-colonized C57BL/6 mice model was tested by a rectal enema with 1 × 10<sup>9</sup> bacteria/day for 3 days. The 5% DSS was added to drinking water for 3 days to induce colitis and diarrhea in experimental mice. The c"],"journal":["Mediators of inflammation"],"pagination":["7280675"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11986197"],"repository":["biostudies-literature"],"pubmed_title":["&lt;i&gt;Faecalibacterium prausnitzii&lt;/i&gt; Colonization Attenuates Gut Inflammation and Epithelial Damage in a DSS-Induced Colitis Mice Model."],"pmcid":["PMC11986197"],"pubmed_authors":["Liu MC","Tseng HY","Yu YT","Wang YC","Shu YA","Tsai PJ","Yang YJ","Li MJ","Cheng HC"],"additional_accession":[]},"is_claimable":false,"name":"&lt;i&gt;Faecalibacterium prausnitzii&lt;/i&gt; Colonization Attenuates Gut Inflammation and Epithelial Damage in a DSS-Induced Colitis Mice Model.","description":"<b>Background:</b> Reduction of <i>Faecalibacterium prausnitzii</i> abundance is related to inflammatory bowel diseases (IBDs), and supplement of it exists protective effects. <b>Aim:</b> This study aimed to establish a <i>F. prausnitzii</i>-colonized mouse model and investigate that the presence of <i>F. prausnitzii</i> in the gut can ameliorate the severity of dextran sulfate sodium (DSS)-induced colitis. <b>Methods:</b> A <i>F. prausnitzii</i> (ATCC 27768) strain was maintained on the PS-BHI agar plates and manipulated in a strictly anaerobic chamber. A <i>F. prausnitzii</i>-colonized C57BL/6 mice model was tested by a rectal enema with 1 × 10<sup>9</sup> bacteria/day for 3 days. The 5% DSS was added to drinking water for 3 days to induce colitis and diarrhea in experimental mice. The c","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-07-08T03:10:16.362Z","creation":"2025-07-08T03:10:16.362Z"},"accession":"S-EPMC11986197","cross_references":{"pubmed":["40224484"],"doi":["10.1155/mi/7280675"]}}