{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["57(3)"],"submitter":["Wang J"],"pubmed_abstract":["The persistent global burden of hepatitis B virus (HBV) infection has prompted ongoing investigations into host determinants of viral control. In this study, we investigate the regulatory influence of the host gene cleavage stimulation factor subunit 2 (CSTF2) on HBV replication dynamics. We demonstrate differential CSTF2 expression across the spectrum of HBV infection phases, with upregulated expression noted during the immune-reactive and inactive carrier states compared with the immune-tolerant phase. Notably, dose-responsive attenuation of HBV DNA, as well as surface and core protein levels, is observed subsequent to CSTF2 overexpression, whereas HBV RNA levels remain unaffected. Upon HBV transfection, a notable alteration in CSTF2 subcellular localization is discerned, suggesting acti"],"journal":["Acta biochimica et biophysica Sinica"],"pagination":["486-496"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11986456"],"repository":["biostudies-literature"],"pubmed_title":["The host gene <i>CSTF2</i> regulates HBV replication via HBV PRE-induced nuclear export."],"pmcid":["PMC11986456"],"pubmed_authors":["Wu J","Xie W","Lu M","Li J","Shen Z","Zhang J","Mao R","Wang J"],"additional_accession":[]},"is_claimable":false,"name":"The host gene <i>CSTF2</i> regulates HBV replication via HBV PRE-induced nuclear export.","description":"The persistent global burden of hepatitis B virus (HBV) infection has prompted ongoing investigations into host determinants of viral control. In this study, we investigate the regulatory influence of the host gene cleavage stimulation factor subunit 2 (CSTF2) on HBV replication dynamics. We demonstrate differential CSTF2 expression across the spectrum of HBV infection phases, with upregulated expression noted during the immune-reactive and inactive carrier states compared with the immune-tolerant phase. Notably, dose-responsive attenuation of HBV DNA, as well as surface and core protein levels, is observed subsequent to CSTF2 overexpression, whereas HBV RNA levels remain unaffected. Upon HBV transfection, a notable alteration in CSTF2 subcellular localization is discerned, suggesting acti","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-06-01T20:14:31.035Z","creation":"2025-07-03T03:04:41.656Z"},"accession":"S-EPMC11986456","cross_references":{"pubmed":["39722572"],"doi":["10.3724/abbs.2024216"]}}