biostudies-literatureUnknown73(14)Rocco CBioavailable ligands that bind metals mediate their uptake in plants, leading to the study of artificial ligands as potential fertilizers. Proline-2'-deoxymugineic acid (PDMA) has shown a high affinity for Fe^III, enhancing iron uptake in rice and suggesting that it could be used for improving zinc uptake. This work studied chemical solution parameters, i.e., redox potential, ion strength, pH, and ligand/metal concentrations controlling Zn^II-PDMA complex formation in rice-producing soils using geochemical speciation modeling. We show that PDMA is generally selective for Zn^II in reducing, saline, and alkaline soil solutions. Comparison with a recent micronutrient uptake study in rice suggests that free PDMA should be added in reducing conditions to avoid compJournal of agricultural and food chemistry8243-8253https://www.ebi.ac.uk/biostudies/studies/S-EPMC11987015biostudies-literatureEnhancing Zinc Bioavailability in Rice Using the Novel Synthetic Siderophore Ligand Proline-2'-Deoxymugineic Acid (PDMA): Critical Insights from Metal Binding Studies and Geochemical Speciation Modeling.PMC11987015Turnbull CSuzuki MCao XWissuwa MVilar RWeiss DBlasco SLarrouy-Maumus GGarcia-Espana ERocco CfalseEnhancing Zinc Bioavailability in Rice Using the Novel Synthetic Siderophore Ligand Proline-2'-Deoxymugineic Acid (PDMA): Critical Insights from Metal Binding Studies and Geochemical Speciation Modeling.Bioavailable ligands that bind metals mediate their uptake in plants, leading to the study of artificial ligands as potential fertilizers. Proline-2'-deoxymugineic acid (PDMA) has shown a high affinity for Fe^III, enhancing iron uptake in rice and suggesting that it could be used for improving zinc uptake. This work studied chemical solution parameters, i.e., redox potential, ion strength, pH, and ligand/metal concentrations controlling Zn^II-PDMA complex formation in rice-producing soils using geochemical speciation modeling. We show that PDMA is generally selective for Zn^II in reducing, saline, and alkaline soil solutions. Comparison with a recent micronutrient uptake study in rice suggests that free PDMA should be added in reducing conditions to avoid comp2025-01-01T00:00:00Z2025 Apr2025-07-12T03:04:12.723Z2025-07-12T03:04:12.723ZS-EPMC119870154014367610.1021/acs.jafc.5c02128