biostudies-literatureUnknown31(1)Placidi M<h4>Background</h4>Endometriosis, a common condition affecting 5-10% of women of reproductive age, is the growth of endometrial-like tissue outside the uterus, leading to pain and infertility. Current treatments, such as surgery and hormonal therapy, offer limited long-term benefits. This study investigated the potential of D-chiro inositol (DCI), a natural compound that influences ovarian steroidogenesis, to treat endometriosis and compared its efficacy with a progestin drug such as Dienogest (DG).<h4>Methods</h4>We established a non-surgical mouse model of endometriosis in CD1 mice. Uterine horns were removed from donor mice, cut into fragments and inoculated in recipient mice by intraperitoneal injection. Endometriosis progression was assessed at 15, 21 and 28 days after transplantationMolecular medicine (Cambridge, Mass.)134https://www.ebi.ac.uk/biostudies/studies/S-EPMC11987403biostudies-literatureD-chiro-inositol effectively counteracts endometriosis in a mouse model.PMC11987403Tatone CBianchi APalmerini MGZaccardi SPlacidi MCasoli GVergara TBevilacqua AMacchiarelli GCocciolone DDi Emidio GfalseD-chiro-inositol effectively counteracts endometriosis in a mouse model.<h4>Background</h4>Endometriosis, a common condition affecting 5-10% of women of reproductive age, is the growth of endometrial-like tissue outside the uterus, leading to pain and infertility. Current treatments, such as surgery and hormonal therapy, offer limited long-term benefits. This study investigated the potential of D-chiro inositol (DCI), a natural compound that influences ovarian steroidogenesis, to treat endometriosis and compared its efficacy with a progestin drug such as Dienogest (DG).<h4>Methods</h4>We established a non-surgical mouse model of endometriosis in CD1 mice. Uterine horns were removed from donor mice, cut into fragments and inoculated in recipient mice by intraperitoneal injection. Endometriosis progression was assessed at 15, 21 and 28 days after transplantation2025-01-01T00:00:00Z2025 Apr2025-07-06T03:04:28.877Z2025-07-06T03:04:28.877ZS-EPMC119874034021111210.1186/s10020-025-01178-6