biostudies-literatureUnknown61(5)Castelein J<h4>Background</h4>Cardiac magnetic resonance elastography (MRE) shows promise in assessing the mechanofunctional properties of the heart but faces clinical challenges, mainly synchronization with cardiac cycle, breathing, and external harmonic stimulation.<h4>Purpose</h4>To determine the reproducibility of in vivo cardiac multifrequency MRE (MMRE) for assessing diastolic left ventricular (LV) stiffness and viscosity.<h4>Study type</h4>Prospective.<h4>Subjects</h4>This single-center study included a total of 28 participants (mean age, 56.6 ± 23.0 years; 16 male) consisting of randomly selected healthy participants (mean age, 44.6 ± 20.1 years; 9 male) and patients with aortic stenosis (mean age, 78.3 ± 3.8 years; 7 male).<h4>Field strength/sequence</h4>3 T, 3D multifrequency MRE with a sinJournal of magnetic resonance imaging : JMRI2146-2154https://www.ebi.ac.uk/biostudies/studies/S-EPMC11987795biostudies-literatureReproducibility of Cardiac Multifrequency MR Elastography in Assessing Left Ventricular Stiffness and Viscosity.PMC11987795Hansen AEKettless KAnders MSDe Backer ODuus ASCastelein JSack IDierckx RAJOVejlstrup NGBorra RJHLund MAVBække PSfalseReproducibility of Cardiac Multifrequency MR Elastography in Assessing Left Ventricular Stiffness and Viscosity.<h4>Background</h4>Cardiac magnetic resonance elastography (MRE) shows promise in assessing the mechanofunctional properties of the heart but faces clinical challenges, mainly synchronization with cardiac cycle, breathing, and external harmonic stimulation.<h4>Purpose</h4>To determine the reproducibility of in vivo cardiac multifrequency MRE (MMRE) for assessing diastolic left ventricular (LV) stiffness and viscosity.<h4>Study type</h4>Prospective.<h4>Subjects</h4>This single-center study included a total of 28 participants (mean age, 56.6 ± 23.0 years; 16 male) consisting of randomly selected healthy participants (mean age, 44.6 ± 20.1 years; 9 male) and patients with aortic stenosis (mean age, 78.3 ± 3.8 years; 7 male).<h4>Field strength/sequence</h4>3 T, 3D multifrequency MRE with a sin2025-01-01T00:00:00Z2025 May2025-07-13T03:06:08.895Z2025-07-13T03:06:08.895ZS-EPMC119877953944954710.1002/jmri.29640