{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Benitez L"],"funding":["Centre for Biomedical Network Research on Rare Diseases","Agència de Gestió d'Ajuts Universitaris i de Recerca","Instituto de Salud Carlos III","Deutsche Forschungsgemeinschaft","INSA-Ma María de Maeztu Unit of Excellence","German Cancer Aid","Universitat de Barcelona","Deutsche José-Carreras Leukämie-Stiftung","Federal Ministry of Education and Research","la caixa"],"pagination":["2971"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11988504"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(7)"],"pubmed_abstract":["<i>ETV6::RUNX1</i>-positive pediatric acute lymphoblastic leukemia frequently has a prenatal origin and follows a two-hit model: a first somatic alteration leads to the formation of the oncogenic fusion gene <i>ETV6::RUNX1</i> and the generation of a preleukemic clone in utero. Secondary hits after birth are necessary to convert the preleukemic clone into clinically overt leukemia. However, prenatal factors triggering the first hit have not yet been determined. Here, we explore the influence of maternal factors during pregnancy on the prevalence of the <i>ETV6::RUNX1</i> fusion. To this end, we employed a nested interventional cohort study (IMPACT-BCN trial), including 1221 pregnancies (randomized into usual care, a Mediterranean diet, or mindfulness-based stress reduction) and determined "],"journal":["International journal of molecular sciences"],"pubmed_title":["Modulation of the &lt;i&gt;ETV6::RUNX1&lt;/i&gt; Gene Fusion Prevalence in Newborns by Corticosteroid Use During Pregnancy."],"pmcid":["PMC11988504"],"funding_grant_id":["DJCLS 18R/2021","01KD2410A","CM21/00058","LCF/PR/ GN18/10310003","70114736","grant 2017 SGR No. 1531","CEX2021-001234-M","INT21/00027","FJC2021-048123-I","PI20/00246","495318549","RD21/0012/0003","Margarita Salas fellowship"],"pubmed_authors":["Fischer U","Crovetto F","Gratacos E","Castro-Barquero S","Larroya M","Youssef L","Borras R","Borkhardt A","Vieta E","Benitez L","Casas R","Crispi F","Kameri E","Bueno C","Estruch R","Menendez P","Castillo H"],"additional_accession":[]},"is_claimable":false,"name":"Modulation of the &lt;i&gt;ETV6::RUNX1&lt;/i&gt; Gene Fusion Prevalence in Newborns by Corticosteroid Use During Pregnancy.","description":"<i>ETV6::RUNX1</i>-positive pediatric acute lymphoblastic leukemia frequently has a prenatal origin and follows a two-hit model: a first somatic alteration leads to the formation of the oncogenic fusion gene <i>ETV6::RUNX1</i> and the generation of a preleukemic clone in utero. Secondary hits after birth are necessary to convert the preleukemic clone into clinically overt leukemia. However, prenatal factors triggering the first hit have not yet been determined. Here, we explore the influence of maternal factors during pregnancy on the prevalence of the <i>ETV6::RUNX1</i> fusion. To this end, we employed a nested interventional cohort study (IMPACT-BCN trial), including 1221 pregnancies (randomized into usual care, a Mediterranean diet, or mindfulness-based stress reduction) and determined ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-07-10T03:08:18.003Z","creation":"2025-07-10T03:08:18.003Z"},"accession":"S-EPMC11988504","cross_references":{"pubmed":["40243620"],"doi":["10.3390/ijms26072971"]}}