{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu Y"],"funding":["Fujian Provincial Natural Science Foundation","National Natural Science Foundation of China","Initial Research Fund of Jimei University"],"pagination":["1260"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11988977"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(7)"],"pubmed_abstract":["Gray mold, caused by <i>Botrytis cinerea</i>, is the primary factor contributing to postharvest losses in table grape fruit. In this study, we have identified amphotericin B (AMB), a natural compound originating from <i>Streptomyces nodosus</i>, as a promising agent in managing postharvest gray mold in table grapes. In vitro experiments demonstrated that 0.2 mg/L AMB achieved an inhibition rate of over 90% against <i>B. cinerea</i> in PDA medium, and in vivo assays on grape berries showed that 200 mg/L AMB treatment could completely suppress the occurrence of gray mold disease. A mechanism analysis found that AMB treatment disrupted the plasma membrane structure, which consequently triggered cellular leakage and induced cell death. Furthermore, AMB application effectively modulated the tra"],"journal":["Foods (Basel, Switzerland)"],"pubmed_title":["Mechanism Analysis of Amphotericin B Controlling Postharvest Gray Mold in Table Grapes."],"pmcid":["PMC11988977"],"funding_grant_id":["ZQ2022011","32202565","2022J05151"],"pubmed_authors":["Ke Y","Wang S","Ren T","Wang Y","Wang J","Wu Y"],"additional_accession":[]},"is_claimable":false,"name":"Mechanism Analysis of Amphotericin B Controlling Postharvest Gray Mold in Table Grapes.","description":"Gray mold, caused by <i>Botrytis cinerea</i>, is the primary factor contributing to postharvest losses in table grape fruit. In this study, we have identified amphotericin B (AMB), a natural compound originating from <i>Streptomyces nodosus</i>, as a promising agent in managing postharvest gray mold in table grapes. In vitro experiments demonstrated that 0.2 mg/L AMB achieved an inhibition rate of over 90% against <i>B. cinerea</i> in PDA medium, and in vivo assays on grape berries showed that 200 mg/L AMB treatment could completely suppress the occurrence of gray mold disease. A mechanism analysis found that AMB treatment disrupted the plasma membrane structure, which consequently triggered cellular leakage and induced cell death. Furthermore, AMB application effectively modulated the tra","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-10T03:08:11.975Z","creation":"2025-07-10T03:08:11.975Z"},"accession":"S-EPMC11988977","cross_references":{"pubmed":["40238543"],"doi":["10.3390/foods14071260"]}}