biostudies-literatureUnknown14(7)Sokou R<b>Background/Objectives</b>: Necrotizing enterocolitis (NEC) is a severe, potentially fatal gastrointestinal disease that primarily affects preterm neonates, especially those with very low birth weight (<1500 g). Despite extensive research, its pathophysiology remains unclear, with NEC considered a spectrum of disorders driven by systemic inflammation, microbiota dysregulation, and intestinal hypoxic injury. Diagnosis is challenging due to its subtle presentation and reliance on clinical and radiographic findings, underscoring the urgent need for reliable early biomarkers. Complete blood count (CBC) is one of the most frequently performed laboratory tests in neonatal care, providing valuable insights associated with hematologic alterations associated with NEC. Given its cost-effectivenessJournal of clinical medicine2530https://www.ebi.ac.uk/biostudies/studies/S-EPMC11989880biostudies-literatureDiagnostic and Prognostic Value of Hematological Parameters in Necrotizing Enterocolitis: A Systematic Review.PMC11989880Sokou RPalioura AEIacovidou NBonovas STsante KAPiovani DMantzios PTsantes AGLianou ALampropoulou KfalseDiagnostic and Prognostic Value of Hematological Parameters in Necrotizing Enterocolitis: A Systematic Review.<b>Background/Objectives</b>: Necrotizing enterocolitis (NEC) is a severe, potentially fatal gastrointestinal disease that primarily affects preterm neonates, especially those with very low birth weight (<1500 g). Despite extensive research, its pathophysiology remains unclear, with NEC considered a spectrum of disorders driven by systemic inflammation, microbiota dysregulation, and intestinal hypoxic injury. Diagnosis is challenging due to its subtle presentation and reliance on clinical and radiographic findings, underscoring the urgent need for reliable early biomarkers. Complete blood count (CBC) is one of the most frequently performed laboratory tests in neonatal care, providing valuable insights associated with hematologic alterations associated with NEC. Given its cost-effectiveness2025-01-01T00:00:00Z2025 Apr2025-07-13T03:04:26.147Z2025-07-13T03:04:26.147ZS-EPMC119898804021797910.3390/jcm14072530