{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Maturana MJ"],"funding":["ANID FONDAP apoyo"],"pagination":["3333"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11989948"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(7)"],"pubmed_abstract":["Restrictions resulting from the COVID-19 pandemic abruptly reversed the slow decline of the diagnosis and mortality rates of gastric cancer (GC). This scenario highlights the importance of developing cost-effective methods for mass screening and evaluation of treatment response. In this study, we evaluated a non-invasive method based on the circulating methylated cell-free DNA (cfDNA) of Reprimo (<i>RPRM</i>), a tumor suppressor gene associated with the development of GC. Methylated <i>RPRM</i> cfDNA was analyzed in three de-identified cohorts: Cohort 1 comprised 81 participants with GC and 137 healthy donors (HDs); Cohort 2 comprised 27 participants with GC undergoing gastrectomy and/or chemotherapy analyzed at the beginning and after three months of treatment; and Cohort 3 comprised 1105"],"journal":["International journal of molecular sciences"],"pubmed_title":["Methylated Reprimo Cell-Free DNA as a Non-Invasive Biomarker for Gastric Cancer."],"pmcid":["PMC11989948"],"funding_grant_id":["1523A0008"],"pubmed_authors":["Santoro PM","Alarcon MA","Blanco A","Garrido M","Calvo-Belmar A","Maturana MJ","Aravena E","Barrientos C","Corvalan AH","Padilla O","Olivares W","Armisen R"],"additional_accession":[]},"is_claimable":false,"name":"Methylated Reprimo Cell-Free DNA as a Non-Invasive Biomarker for Gastric Cancer.","description":"Restrictions resulting from the COVID-19 pandemic abruptly reversed the slow decline of the diagnosis and mortality rates of gastric cancer (GC). This scenario highlights the importance of developing cost-effective methods for mass screening and evaluation of treatment response. In this study, we evaluated a non-invasive method based on the circulating methylated cell-free DNA (cfDNA) of Reprimo (<i>RPRM</i>), a tumor suppressor gene associated with the development of GC. Methylated <i>RPRM</i> cfDNA was analyzed in three de-identified cohorts: Cohort 1 comprised 81 participants with GC and 137 healthy donors (HDs); Cohort 2 comprised 27 participants with GC undergoing gastrectomy and/or chemotherapy analyzed at the beginning and after three months of treatment; and Cohort 3 comprised 1105","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-07T03:10:10.046Z","creation":"2025-07-07T03:10:10.046Z"},"accession":"S-EPMC11989948","cross_references":{"pubmed":["40244164"],"doi":["10.3390/ijms26073333"]}}