biostudies-literatureChen SJing Lin,Shunming Zhang1282https://www.ebi.ac.uk/biostudies/studies/S-EPMC11990840biostudies-literatureUnknown17(7)(1) Background: Diet plays a crucial role in the intake of phytoestrogens, which are closely related to the pathogenesis of some pregnancy complications. However, no studies have explored the potential association between soy isoflavones, a type of phytoestrogen, and the risk of hyperemesis gravidarum (HG). This study aims to investigate the correlation between dietary intake of soy isoflavones and the risk of HG. (2) Methods: As part of the China Birth Cohort Study (CBCS), 2418 pregnant Chinese women (mean age: 31.2 ± 3.4 years) were enrolled between April 2021 and September 2022. Dietary intake was evaluated using a validated 108-item semi-quantitative food frequency questionnaire, with soy isoflavones intake estimated based on five food groups. HG was defined as a condition characterizeNutrientsAssociation Between Dietary Soy Isoflavones Intake and the Risk of Hyperemesis Gravidarum: A Cross-Sectional Study in Chinese Pregnant Women.PMC11990840Natural Science Foundation of Shaanxi Province, grant number 2023-JC-QN-0895; Science Research on Chronic Disease Prevention in Children, grant number 202208159; and the Young Elite Scientists Sponsorship Program by CAST (No. 2023QNRC001).Ma QMa LZhang XZhang LLin JChen SCheng WJin YZhang SfalseAssociation Between Dietary Soy Isoflavones Intake and the Risk of Hyperemesis Gravidarum: A Cross-Sectional Study in Chinese Pregnant Women.(1) Background: Diet plays a crucial role in the intake of phytoestrogens, which are closely related to the pathogenesis of some pregnancy complications. However, no studies have explored the potential association between soy isoflavones, a type of phytoestrogen, and the risk of hyperemesis gravidarum (HG). This study aims to investigate the correlation between dietary intake of soy isoflavones and the risk of HG. (2) Methods: As part of the China Birth Cohort Study (CBCS), 2418 pregnant Chinese women (mean age: 31.2 ± 3.4 years) were enrolled between April 2021 and September 2022. Dietary intake was evaluated using a validated 108-item semi-quantitative food frequency questionnaire, with soy isoflavones intake estimated based on five food groups. HG was defined as a condition characterize2025-01-01T00:00:00Z2025 Apr2025-07-14T03:02:42.487Z2025-07-14T03:02:42.487ZS-EPMC119908404021903910.3390/nu17071282