{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Coles NP"],"funding":["Biotechnology and Biological Sciences Research Council"],"pagination":["fcaf133"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11992568"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(2)"],"pubmed_abstract":["The aggregation of α-synuclein is a central neuropathological hallmark in neurodegenerative disorders known as Lewy body diseases, including Parkinson's disease and dementia with Lewy bodies. In the aggregation process, α-synuclein transitions from its native disordered/α-helical form to a β-sheet-rich structure, forming oligomers and protofibrils that accumulate into Lewy bodies, in a process that is thought to underlie neurodegeneration. Lipids are thought to play a critical role in this process by facilitating α-synuclein aggregation and contributing to cell toxicity, possibly through ceramide production. This study aimed to investigate biochemical changes associated with α-synuclein aggregation, focusing on lipid changes, using Raman spectroscopy coupled with machine learning. HEK293, "],"journal":["Brain communications"],"pubmed_title":["Alpha-synuclein aggregation induces prominent cellular lipid changes as revealed by Raman spectroscopy and machine learning analysis."],"pmcid":["PMC11992568"],"funding_grant_id":["BB/R013942/1"],"pubmed_authors":["Quesnel A","Koss DJ","Coles NP","Angione C","Occhipinti A","Achadu O","Marles-Wright J","Kalesh K","Thomas AJ","Filippou PS","Outeiro TF","Khundakar AA","Islam M","Elsheikh S","Butler L"],"additional_accession":[]},"is_claimable":false,"name":"Alpha-synuclein aggregation induces prominent cellular lipid changes as revealed by Raman spectroscopy and machine learning analysis.","description":"The aggregation of α-synuclein is a central neuropathological hallmark in neurodegenerative disorders known as Lewy body diseases, including Parkinson's disease and dementia with Lewy bodies. In the aggregation process, α-synuclein transitions from its native disordered/α-helical form to a β-sheet-rich structure, forming oligomers and protofibrils that accumulate into Lewy bodies, in a process that is thought to underlie neurodegeneration. Lipids are thought to play a critical role in this process by facilitating α-synuclein aggregation and contributing to cell toxicity, possibly through ceramide production. This study aimed to investigate biochemical changes associated with α-synuclein aggregation, focusing on lipid changes, using Raman spectroscopy coupled with machine learning. HEK293, ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-07-13T03:04:15.123Z","creation":"2025-07-13T03:04:15.123Z"},"accession":"S-EPMC11992568","cross_references":{"pubmed":["40226383"],"doi":["10.1093/braincomms/fcaf133"]}}