{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(4)"],"submitter":["van den Berg W"],"funding":["Natural Sciences and Engineering Research Council of Canada"],"pubmed_abstract":["The nematodes Caenorhabditis briggsae and its well-known cousin Caenorhabditis elegans offer many features for comparative investigations of genetic pathways that affect physiological processes. Reproduction is one such process that directly impacts longevity due to its significant energetic demands. To study gene expression changes during reproductive and post-reproductive phases in both these nematodes, we conducted whole-genome transcriptome profiling at various adult stages. The results revealed that the majority of differentially expressed (DE) genes were downregulated during the reproductive period in both species. Interestingly, in C. briggsae, this trend reversed during post-reproduction, with three-quarters of the DE genes becoming upregulated. Additionally, a smaller set of DE ge"],"journal":["Genome biology and evolution"],"pagination":["evaf057"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11992569"],"repository":["biostudies-literature"],"pubmed_title":["Genome-Wide Temporal Gene Expression Reveals a Post-Reproductive Shift in the Nematode Caenorhabditis briggsae."],"pmcid":["PMC11992569"],"pubmed_authors":["Gupta BP","van den Berg W"],"additional_accession":[]},"is_claimable":false,"name":"Genome-Wide Temporal Gene Expression Reveals a Post-Reproductive Shift in the Nematode Caenorhabditis briggsae.","description":"The nematodes Caenorhabditis briggsae and its well-known cousin Caenorhabditis elegans offer many features for comparative investigations of genetic pathways that affect physiological processes. Reproduction is one such process that directly impacts longevity due to its significant energetic demands. To study gene expression changes during reproductive and post-reproductive phases in both these nematodes, we conducted whole-genome transcriptome profiling at various adult stages. The results revealed that the majority of differentially expressed (DE) genes were downregulated during the reproductive period in both species. Interestingly, in C. briggsae, this trend reversed during post-reproduction, with three-quarters of the DE genes becoming upregulated. Additionally, a smaller set of DE ge","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-07-03T03:28:01.135Z","creation":"2025-07-13T03:04:42.534Z"},"accession":"S-EPMC11992569","cross_references":{"pubmed":["40171711"],"doi":["10.1093/gbe/evaf057"]}}