{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Maina MB"],"funding":["National Institute of Neurological Disorders and Stroke","NCATS NIH HHS","NIA NIH HHS","National Institutes of Health","Alzheimer&apos;s Association","National Institute on Aging","Tau Consortium","National Institutes for Health","Care Research University College London Hospitals Biomedical Research Centre","NINDS NIH HHS","Rainwater Charitable Foundation","Alzheimer's Association","Wellcome Trust","NIH HHS"],"pagination":["e70145"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11992592"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(4)"],"pubmed_abstract":["<h4>Introduction</h4>Africa, home to 1.4 billion people and the highest genetic diversity globally, harbors unique genetic variants crucial for understanding complex diseases like neurodegenerative disorders. However, African populations remain underrepresented in induced pluripotent stem cell (iPSC) collections, limiting the exploration of population-specific disease mechanisms and therapeutic discoveries.<h4>Methods</h4>To address this gap, we established an open-access African Somatic and Stem Cell Bank.<h4>Results</h4>In this initial phase, we generated 10 rigorously characterized iPSC lines from fibroblasts representing five Nigerian ethnic groups and both sexes. These lines underwent extensive profiling for pluripotency, genetic stability, differentiation potential, and Alzheimer's d"],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Somatic and Stem Cell Bank to study the contribution of African ancestry to dementia: African iPSC Initiative."],"pmcid":["PMC11992592"],"funding_grant_id":["R56 NS110890","K01 AG083215","NS110890","U19 AG069701","UL1 TR002345","UL1TR002345","AG083215","R61 NS138655","U01 AG072464","RF1 NS110890","U24 AG074855","P30 AG066444","R01 NS110890"],"pubmed_authors":["Lee S","Miller N","Starr E","Marsh JA","Minaya M","Harari O","Aladyeva E","Isah MB","Serpell LC","Wray S","Goni BW","Maina MB","Idris AA","Miller KJ","Karch CM","Babazau L","Muhammad Z"],"additional_accession":[]},"is_claimable":false,"name":"Somatic and Stem Cell Bank to study the contribution of African ancestry to dementia: African iPSC Initiative.","description":"<h4>Introduction</h4>Africa, home to 1.4 billion people and the highest genetic diversity globally, harbors unique genetic variants crucial for understanding complex diseases like neurodegenerative disorders. However, African populations remain underrepresented in induced pluripotent stem cell (iPSC) collections, limiting the exploration of population-specific disease mechanisms and therapeutic discoveries.<h4>Methods</h4>To address this gap, we established an open-access African Somatic and Stem Cell Bank.<h4>Results</h4>In this initial phase, we generated 10 rigorously characterized iPSC lines from fibroblasts representing five Nigerian ethnic groups and both sexes. These lines underwent extensive profiling for pluripotency, genetic stability, differentiation potential, and Alzheimer's d","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-07-15T11:03:57.744Z","creation":"2025-07-13T03:04:25.901Z"},"accession":"S-EPMC11992592","cross_references":{"pubmed":["40219788"],"doi":["10.1002/alz.70145"]}}