biostudies-literatureUnknown45(9)Kataike VMOxygen Extraction Fraction (OEF) is a critical measure of a tissue's metabolic state post-ischemic stroke. This study investigated OEF changes in stroke-affected tissue compared to healthy tissue, post-reperfusion. OEF maps generated from gradient echo MRI images of 87 ischemic stroke patients at three time points after successful Endovascular Thrombectomy (EVT) were analysed in a prospective longitudinal multicentre study. Regions of interest (ROIs) delineating the infarct areas and corresponding mirror regions were drawn. The MR-derived OEF index values were obtained from the ROIs and compared using Wilcoxon signed rank tests. The cross-sectional comparison of OEF index values revealed lower values in the infarct areas than the corresponding contralateral areas at all three time points aJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism1748-1759https://www.ebi.ac.uk/biostudies/studies/S-EPMC11993554biostudies-literatureOxygen extraction fraction changes in ischemic tissue from 24-72 hours to 12 months after successful reperfusion.PMC11993554Venkatraman VKataike VMDesmond PMMitchell PJCampbell BCSteward CNg FfalseOxygen extraction fraction changes in ischemic tissue from 24-72 hours to 12 months after successful reperfusion.Oxygen Extraction Fraction (OEF) is a critical measure of a tissue's metabolic state post-ischemic stroke. This study investigated OEF changes in stroke-affected tissue compared to healthy tissue, post-reperfusion. OEF maps generated from gradient echo MRI images of 87 ischemic stroke patients at three time points after successful Endovascular Thrombectomy (EVT) were analysed in a prospective longitudinal multicentre study. Regions of interest (ROIs) delineating the infarct areas and corresponding mirror regions were drawn. The MR-derived OEF index values were obtained from the ROIs and compared using Wilcoxon signed rank tests. The cross-sectional comparison of OEF index values revealed lower values in the infarct areas than the corresponding contralateral areas at all three time points a2025-01-01T00:00:00Z2025 Sep2026-05-29T20:10:25.164Z2026-04-08T05:58:27.444ZS-EPMC119935544021984510.1177/0271678X251333940