biostudies-literatureUnknown20Kiwan P<h4>Background</h4>The Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen known to cause severe viral hemorrhagic fever.<h4>Aim</h4>We aimed to evaluate the potential circulation of CCHFV in Corsica through a serosurvey, including anonymized residual sera (RS) and high-risk individuals exposed to animals and/or tick bites due to occupational activities.<h4>Methods</h4>This cross-sectional study involved two groups: anonymized RS from medical biology laboratories and sera from high-risk individuals (slaughterhouse workers, veterinary professionals, animal farmers, and rangers) collected across Corsica during 2022-2023. Antibodies targeting the CCHFV viral nucleoprotein were detected using a double-antigen ELISA. ELISA-positive samples underwent neutralizing antibody testOne health (Amsterdam, Netherlands)101020https://www.ebi.ac.uk/biostudies/studies/S-EPMC11995033biostudies-literatureSerological evaluation of Crimean-Congo Hemorrhagic fever in humans with High-Risk professional exposure and in residual sera collected in 2022-2023 across Corsica (France).PMC11995033Decarreaux DAvsic-Zupanc TSimeoni MHCanarelli JMasse SGasparine MCapai LFalchi ACharrel RKiwan PKorva Mde Lamballerie XfalseSerological evaluation of Crimean-Congo Hemorrhagic fever in humans with High-Risk professional exposure and in residual sera collected in 2022-2023 across Corsica (France).<h4>Background</h4>The Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen known to cause severe viral hemorrhagic fever.<h4>Aim</h4>We aimed to evaluate the potential circulation of CCHFV in Corsica through a serosurvey, including anonymized residual sera (RS) and high-risk individuals exposed to animals and/or tick bites due to occupational activities.<h4>Methods</h4>This cross-sectional study involved two groups: anonymized RS from medical biology laboratories and sera from high-risk individuals (slaughterhouse workers, veterinary professionals, animal farmers, and rangers) collected across Corsica during 2022-2023. Antibodies targeting the CCHFV viral nucleoprotein were detected using a double-antigen ELISA. ELISA-positive samples underwent neutralizing antibody test2025-01-01T00:00:00Z2025 Jun2025-07-10T03:08:29.416Z2025-07-10T03:08:29.416ZS-EPMC119950334023058410.1016/j.onehlt.2025.101020