{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["DeCaen PG"],"funding":["This study was supported by The São Paulo Research Foundation (FAPESP) (2019/05882-8, 2019/26414-2) and the National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK123463-01, R01 DK131118-01).","NIDDK NIH HHS"],"pagination":["e70034"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11996007"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["240(4)"],"pubmed_abstract":["Primary cilia are polymodal sensory organelles which project from the apical side of polarized cells. They are found in all brain hemispheres but are most pronounced in neurons, which comprise the granular layers of the hippocampus and cerebellum. Pathogenic variants in genes which encode primary cilia components are responsible for neuronal ciliopathies-a group of central nervous system disorders characterized by neurodevelopmental conditions such as intellectual disability, seizure, ataxia, and sensory deficits. In the hippocampus, neuronal primary cilia form chemical synapses with axons and their membranes are populated with unique sets of ion channels and G protein-coupled receptors (GPCRs). Primary cilia are small and privileged compartments that are challenging organelles to study. I"],"journal":["Journal of cellular physiology"],"pubmed_title":["Methods to Assess Neuronal Primary Cilia Electrochemical Signaling."],"pmcid":["PMC11996007"],"funding_grant_id":["R01 DK131118","R01 DK123463"],"pubmed_authors":["DeCaen PG","Kimura LF"],"additional_accession":[]},"is_claimable":false,"name":"Methods to Assess Neuronal Primary Cilia Electrochemical Signaling.","description":"Primary cilia are polymodal sensory organelles which project from the apical side of polarized cells. They are found in all brain hemispheres but are most pronounced in neurons, which comprise the granular layers of the hippocampus and cerebellum. Pathogenic variants in genes which encode primary cilia components are responsible for neuronal ciliopathies-a group of central nervous system disorders characterized by neurodevelopmental conditions such as intellectual disability, seizure, ataxia, and sensory deficits. In the hippocampus, neuronal primary cilia form chemical synapses with axons and their membranes are populated with unique sets of ion channels and G protein-coupled receptors (GPCRs). Primary cilia are small and privileged compartments that are challenging organelles to study. I","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-06-28T03:05:33.411Z","creation":"2025-06-28T03:05:33.411Z"},"accession":"S-EPMC11996007","cross_references":{"pubmed":["40227694"],"doi":["10.1002/jcp.70034"]}}