{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu K"],"funding":["Innovative research team of high-level local universities in Shanghai and the 111 project","State Key Laboratory of System Medicine for Cancer","Ren Ji Hospital","National Natural Science Foundation of China","Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support","Shanghai Pilot Program for Basic Research-Shanghai Jiao Tong University","Renji Hospital foundation","Collaborative Innovation Center for Clinical and Translational Science by Ministry of Education & Shanghai"],"pagination":["e183544"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11996869"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["135(8)"],"pubmed_abstract":["Serotonin (5-HT) is a neurotransmitter that has been linked to tumorigenesis. Whether and how 5-HT modulates cells in the microenvironment to regulate tumor metastasis is largely unknown. Here, we demonstrate that 5-HT was secreted by neuroendocrine prostate cancer (NEPC) cells to communicate with neutrophils and to induce the formation of neutrophil extracellular traps (NETs) in the liver, which in turn facilitated the recruitment of disseminated cancer cells and promoted liver metastasis. 5-HT induced histone serotonylation (H3Q5ser) and orchestrated histone citrullination (H3cit) in neutrophils to trigger chromatin decondensation and facilitate the formation of NETs. Interestingly, we uncovered in this process a reciprocally reinforcing effect between H3Q5ser and H3cit and a crosstalk b"],"journal":["The Journal of clinical investigation"],"pubmed_title":["5-HT orchestrates histone serotonylation and citrullination to drive neutrophil extracellular traps and liver metastasis."],"pmcid":["PMC11996869"],"funding_grant_id":["CCTS-202402","NSFC82372873","KF2413","21TQ1400225","NSFC-U23A20454","B21024","82472909","RJZH25-005","RJTJ24-MS-026","20181706"],"pubmed_authors":["Cheng C","Liu K","Jiang L","Xu P","Zhao C","Zhang K","Jing N","Wang D","Sun Y","Wang J","Zhang P","Liu Y","Xue W","Pan J","Jiang SH","Xiao L","Zhang ZG","Gao WQ","Zhang Y","Du G","Zhu HH","Chen X","Zhao H"],"additional_accession":[]},"is_claimable":false,"name":"5-HT orchestrates histone serotonylation and citrullination to drive neutrophil extracellular traps and liver metastasis.","description":"Serotonin (5-HT) is a neurotransmitter that has been linked to tumorigenesis. Whether and how 5-HT modulates cells in the microenvironment to regulate tumor metastasis is largely unknown. Here, we demonstrate that 5-HT was secreted by neuroendocrine prostate cancer (NEPC) cells to communicate with neutrophils and to induce the formation of neutrophil extracellular traps (NETs) in the liver, which in turn facilitated the recruitment of disseminated cancer cells and promoted liver metastasis. 5-HT induced histone serotonylation (H3Q5ser) and orchestrated histone citrullination (H3cit) in neutrophils to trigger chromatin decondensation and facilitate the formation of NETs. Interestingly, we uncovered in this process a reciprocally reinforcing effect between H3Q5ser and H3cit and a crosstalk b","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-03T03:04:21.699Z","creation":"2025-07-03T03:04:21.699Z"},"accession":"S-EPMC11996869","cross_references":{"pubmed":["39903533"],"doi":["10.1172/JCI183544"]}}