{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Y"],"funding":["NIAID NIH HHS","Massachusetts General Hospital Department of Emergency Medicine Fellowship/Eleanor and Miles Shore Faculty Development Awards Program Harvard University William F. Milton Fund","U.S. Department of Health & Human Services | National Institutes of Health (NIH)","Harvard University","U.S. Department of Health &amp; Human Services | National Institutes of Health","NIH HHS"],"pagination":["3556"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11997043"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Infants with severe bronchiolitis (i.e., bronchiolitis requiring hospitalization) face increased risks of respiratory diseases in childhood. We conduct epigenome-wide association studies in a multi-ethnic cohort of these infants. We identify 61 differentially methylated regions in infant blood (<1 year of age) associated with recurrent wheezing by age 3 (170 cases, 318 non-cases) and/or asthma by age 6 (112 cases, 394 non-cases). These differentially methylated regions are enriched in the enhancers of peripheral blood neutrophils. Several differentially methylated regions exhibit interaction with rhinovirus infection and/or specific blood cell types. In the same blood samples, circulating levels of 104 proteins correlate with the differentially methylated regions, and many proteins show ph"],"journal":["Nature communications"],"pubmed_title":["Epigenomic and proteomic analyses provide insights into early-life immune regulation and asthma development in infants."],"pmcid":["PMC11997043"],"funding_grant_id":["R01 AI134940","R01 AI-137091","R01 AI-114552","R01 AI-148338","Harvard University William F. Milton Fund","R01 AI127507","UG3 OD023253","K01 AI-153558","UG3/UH3 OD-023253","U01 AI087881","R01 AI114552","R01 AI148338","R01 AI-134940","R01 AI137091","U01 AI-087881","K01 AI153558","R01 AI-127507"],"pubmed_authors":["Li Y","Zhu Z","Espinola JA","Liang L","Camargo CA","Hasegawa K"],"additional_accession":[]},"is_claimable":false,"name":"Epigenomic and proteomic analyses provide insights into early-life immune regulation and asthma development in infants.","description":"Infants with severe bronchiolitis (i.e., bronchiolitis requiring hospitalization) face increased risks of respiratory diseases in childhood. We conduct epigenome-wide association studies in a multi-ethnic cohort of these infants. We identify 61 differentially methylated regions in infant blood (<1 year of age) associated with recurrent wheezing by age 3 (170 cases, 318 non-cases) and/or asthma by age 6 (112 cases, 394 non-cases). These differentially methylated regions are enriched in the enhancers of peripheral blood neutrophils. Several differentially methylated regions exhibit interaction with rhinovirus infection and/or specific blood cell types. In the same blood samples, circulating levels of 104 proteins correlate with the differentially methylated regions, and many proteins show ph","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-14T03:02:43.085Z","creation":"2025-07-14T03:02:43.085Z"},"accession":"S-EPMC11997043","cross_references":{"pubmed":["40229234"],"doi":["10.1038/s41467-025-57288-6"]}}