{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(1)"],"submitter":["Luo Q"],"pubmed_abstract":["In recent decades, Acinetobacter baumannii has become a major global nosocomial pathogen, with bloodstream infections (BSIs) exhibiting mortality rates exceeding 60% and imposing substantial economic burdens. However, limited large-scale genomic epidemiology has hindered understanding of its population dynamics. Here, we analyzed 1506 non-repetitive BSI-causing A. baumannii isolates from 76 Chinese hospitals over a decade (2011-2021). We identified 149 sequence types (STs) and 101 K-locus types (KLs), revealing increased population diversity. International clone (IC) 2 accounted for 81.74% of isolates, with a notable shift in prevalent STs: ST208 increased while ST191 and ST195 declined, aligning with global trends. ST208 exhibited higher virulence, greater antibiotic resistance, enhanced "],"journal":["Nature communications"],"pagination":["3536"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11997098"],"repository":["biostudies-literature"],"pubmed_title":["Genomic epidemiology and phylodynamics of Acinetobacter baumannii bloodstream isolates in China."],"pmcid":["PMC11997098"],"pubmed_authors":["Zhang E","Hu S","Huang D","Shen J","Dong Y","Quan B","Shen P","Zhang H","Hu X","Man S","Wang D","Zhang L","Luan L","Guo Q","Wang J","Zhang Q","Wang L","Zhang P","Kang H","Guo L","Dong H","Ying C","Wang S","Liang J","Liang K","Chen Y","Zhang B","Xia X","Li J","Xu R","He H","Qiao D","Li F","Chen F","Jin Y","Xu H","Li X","Li Y","Li Z","Lu G","Yang Q","Lu P","BRICS Working Group","Ding H","Cao J","Ma Y","Mao H","Liu Q","Qiang X","Dai Y","Liu Y","Liu Z","Jiang X","Zheng L","Liao G","Yu W","Geng Y","Li A","Yin Y","Chang M","Xiao Y","Song D","Ji J","Zhu H","Xiao T","Zhou Y","Yan X","Kong H","Song J","Luo Q","Huang Y","Zhang Y","Meng L","Liu D","Han C","Tian P"],"additional_accession":[]},"is_claimable":false,"name":"Genomic epidemiology and phylodynamics of Acinetobacter baumannii bloodstream isolates in China.","description":"In recent decades, Acinetobacter baumannii has become a major global nosocomial pathogen, with bloodstream infections (BSIs) exhibiting mortality rates exceeding 60% and imposing substantial economic burdens. However, limited large-scale genomic epidemiology has hindered understanding of its population dynamics. Here, we analyzed 1506 non-repetitive BSI-causing A. baumannii isolates from 76 Chinese hospitals over a decade (2011-2021). We identified 149 sequence types (STs) and 101 K-locus types (KLs), revealing increased population diversity. International clone (IC) 2 accounted for 81.74% of isolates, with a notable shift in prevalent STs: ST208 increased while ST191 and ST195 declined, aligning with global trends. ST208 exhibited higher virulence, greater antibiotic resistance, enhanced ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-07-15T08:54:18.323Z","creation":"2025-07-10T03:08:29.547Z"},"accession":"S-EPMC11997098","cross_references":{"pubmed":["40229304"],"doi":["10.1038/s41467-025-58772-9"]}}