biostudies-literatureUnknown16(1)Luo QIn recent decades, Acinetobacter baumannii has become a major global nosocomial pathogen, with bloodstream infections (BSIs) exhibiting mortality rates exceeding 60% and imposing substantial economic burdens. However, limited large-scale genomic epidemiology has hindered understanding of its population dynamics. Here, we analyzed 1506 non-repetitive BSI-causing A. baumannii isolates from 76 Chinese hospitals over a decade (2011-2021). We identified 149 sequence types (STs) and 101 K-locus types (KLs), revealing increased population diversity. International clone (IC) 2 accounted for 81.74% of isolates, with a notable shift in prevalent STs: ST208 increased while ST191 and ST195 declined, aligning with global trends. ST208 exhibited higher virulence, greater antibiotic resistance, enhanced Nature communications3536https://www.ebi.ac.uk/biostudies/studies/S-EPMC11997098biostudies-literatureGenomic epidemiology and phylodynamics of Acinetobacter baumannii bloodstream isolates in China.PMC11997098Zhang EHu SHuang DShen JDong YQuan BShen PZhang HHu XMan SWang DZhang LLuan LGuo QWang JZhang QWang LZhang PKang HGuo LDong HYing CWang SLiang JLiang KChen YZhang BXia XLi JXu RHe HQiao DLi FChen FJin YXu HLi XLi YLi ZLu GYang QLu PBRICS Working GroupDing HCao JMa YMao HLiu QQiang XDai YLiu YLiu ZJiang XZheng LLiao GYu WGeng YLi AYin YChang MXiao YSong DJi JZhu HXiao TZhou YYan XKong HSong JLuo QHuang YZhang YMeng LLiu DHan CTian PfalseGenomic epidemiology and phylodynamics of Acinetobacter baumannii bloodstream isolates in China.In recent decades, Acinetobacter baumannii has become a major global nosocomial pathogen, with bloodstream infections (BSIs) exhibiting mortality rates exceeding 60% and imposing substantial economic burdens. However, limited large-scale genomic epidemiology has hindered understanding of its population dynamics. Here, we analyzed 1506 non-repetitive BSI-causing A. baumannii isolates from 76 Chinese hospitals over a decade (2011-2021). We identified 149 sequence types (STs) and 101 K-locus types (KLs), revealing increased population diversity. International clone (IC) 2 accounted for 81.74% of isolates, with a notable shift in prevalent STs: ST208 increased while ST191 and ST195 declined, aligning with global trends. ST208 exhibited higher virulence, greater antibiotic resistance, enhanced 2025-01-01T00:00:00Z2025 Apr2026-07-15T08:54:18.323Z2025-07-10T03:08:29.547ZS-EPMC119970984022930410.1038/s41467-025-58772-9