biostudies-literatureBao JNIA NIH HHS3524https://www.ebi.ac.uk/biostudies/studies/S-EPMC11997130biostudies-literatureUnknown16(1)Brain imaging genomics has manifested considerable potential in illuminating the genetic determinants of human brain structure and function. This has propelled us to develop the GIANT (Genetically Informed brAiN aTlas) that accounts for genetic and neuroanatomical variations simultaneously. Integrating voxel-wise heritability and spatial proximity, GIANT clusters brain voxels into genetically informed regions, while retaining fundamental anatomical knowledge. Compared to conventional (non-genetics) brain atlases, GIANT exhibits smaller intra-region variations and larger inter-region variations in terms of voxel-wise heritability. As a result, GIANT yields increased regional SNP heritability, enhanced polygenicity, and its polygenic risk score explains more brain volumetric variation than tNature communicationsA genetically informed brain atlas for enhancing brain imaging genomics.PMC11997130U01 AG066833R01 AG071470RF1 AG063481R01 AG071174U01 AG024904U01 AG068057RF1 AG068191Lacy KShen LCrawford KBernard MDi Benedetto JLoPresti BKaddurah-Daouk RHoang IWan YSaito NStrong JMiller MJKarlawish JCarrillo MJin CVillemagne VOkonkwo OSilverberg NParkins SSalazar JLee VMYMasliah EMontine TShaffer ESachdev PPizzola JFidell AFrank RGermano KKJenkins CNudelman KWalter STosun DGrill JGonzalez HLee EBRobison JMolchan SKim DThao MSAyo ONeu SBuckholtz NToga AWZhao YShivakumar MKhachaturian ZThomas LMasterman DConti CCabrera YRisacher SLChang CPerrin RJBoatwright VAisen PClanton TMahboubi PWebb CForoud TMZhao BWeiner MSnyder PJGuzman VHarkins KRaman RGlittenberg MTalavera SZimmerman CCui YCraft HJo TApostolova LGWen ZBeckett LJack CRLandau SFockler JKwang WAjayi AKoeppe RAAshford MDavatzikos CWen JHussen KAWeisensel TGreen RCAmaza HKachaturian ZChen JBarnes LHo CErus GLargent EHergesheimer LPotter ZYang ZRabinovici GPotter WNho KKorecka MYang SHarvey DDiaz AFranklin ERyan LDrake EKormos ALong QAlzheimer’s Disease Neuroimaging InitiativeNosheny RAdegoke ORivera-Mindt MBao JRafii MOgwang SMorris JErickson CFlenniken DBrylska MMu SJackson JSaykin AJJagust WHsiao JKMagana FSacrey DTTrojanowki JQDonohue MJimenez GFaber KSmith SDuong-Tran DShaw LMPetersen RfalseA genetically informed brain atlas for enhancing brain imaging genomics.Brain imaging genomics has manifested considerable potential in illuminating the genetic determinants of human brain structure and function. This has propelled us to develop the GIANT (Genetically Informed brAiN aTlas) that accounts for genetic and neuroanatomical variations simultaneously. Integrating voxel-wise heritability and spatial proximity, GIANT clusters brain voxels into genetically informed regions, while retaining fundamental anatomical knowledge. Compared to conventional (non-genetics) brain atlases, GIANT exhibits smaller intra-region variations and larger inter-region variations in terms of voxel-wise heritability. As a result, GIANT yields increased regional SNP heritability, enhanced polygenicity, and its polygenic risk score explains more brain volumetric variation than t2025-01-01T00:00:00Z2025 Apr2026-06-01T20:41:05.109Z2025-07-03T03:06:20.82ZS-EPMC119971304022925010.1038/s41467-025-57636-6