{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Aziz-Zadeh L"],"funding":["NICHD NIH HHS","Nedra Gillette Endowed Research Fellowship","U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","U.S. Department of Defense","U.S. Department of Defense (United States Department of Defense)","U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development"],"pagination":["3465"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11997199"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["While it has been suggested that alterations in the composition of gut microbial metabolites may play a causative role in the pathophysiology of autism spectrum disorder (ASD), it is not known how gut microbial metabolites are associated with ASD-specific brain alterations. In this cross-sectional, case-control observational study, (i) fecal metabolomics, (ii) task-based functional magnetic resonance imaging (fMRI), and (iii) behavioral assessments were obtained from 43 ASD and 41 neurotypical (NT) children, aged 8-17. The fMRI tasks used socio-emotional and sensory paradigms that commonly reveal strong evoked brain differences in ASD participants. Our results show that fecal levels of specific tryptophan-related metabolites, including kynurenate, were significantly lower in ASD compared t"],"journal":["Nature communications"],"pubmed_title":["Relationships between brain activity, tryptophan-related gut metabolites, and autism symptomatology."],"pmcid":["PMC11997199"],"funding_grant_id":["R01 HD079432","AR170062","R01HD079432"],"pubmed_authors":["Tanartkit S","Jacobs JP","Bhatt RR","Ringold SM","Labus JS","Aziz-Zadeh L","Dapretto M","Jayashankar A","Butera C","Mayer EA","Kilroy E","Mahurkar-Joshi S"],"additional_accession":[]},"is_claimable":false,"name":"Relationships between brain activity, tryptophan-related gut metabolites, and autism symptomatology.","description":"While it has been suggested that alterations in the composition of gut microbial metabolites may play a causative role in the pathophysiology of autism spectrum disorder (ASD), it is not known how gut microbial metabolites are associated with ASD-specific brain alterations. In this cross-sectional, case-control observational study, (i) fecal metabolomics, (ii) task-based functional magnetic resonance imaging (fMRI), and (iii) behavioral assessments were obtained from 43 ASD and 41 neurotypical (NT) children, aged 8-17. The fMRI tasks used socio-emotional and sensory paradigms that commonly reveal strong evoked brain differences in ASD participants. Our results show that fecal levels of specific tryptophan-related metabolites, including kynurenate, were significantly lower in ASD compared t","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-12T03:04:35.931Z","creation":"2025-07-12T03:04:35.931Z"},"accession":"S-EPMC11997199","cross_references":{"pubmed":["40229237"],"doi":["10.1038/s41467-025-58459-1"]}}