{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["33(4)"],"submitter":["Li Y"],"funding":["Chinese Academy of Sciences","University Grants Committee","National Key Research and Development Program of China Stem Cell and Translational Research","National Natural Science Foundation of China","Hefei Comprehensive National Science Center","Anhui Provincial Natural Science Foundation"],"pubmed_abstract":["Natural killer (NK) cell-based immunotherapy shows promise in cancer treatment, but its efficacy remains limited, necessitating the development of novel strategies. In this study, we demonstrate that the epigenetic factor bromodomain PHD-finger containing transcription factor (BPTF) hinders hepatocellular carcinoma (HCC) recognition by NK cells through its PHD finger's interpretation of H3K4me3. We have generated a small-molecule proteolysis-targeting chimera (PROTAC) that selectively degrades human and murine BPTF. The degradation of BPTF using PROTACs directly enhances the abundance of natural cytotoxicity receptor ligands on HCC cells, facilitating their recognition by NK cells and thereby augmenting NK cell cytotoxicity against HCC both in vitro and in vivo. Through multidisciplinary t"],"journal":["Molecular therapy : the journal of the American Society of Gene Therapy"],"pagination":["1566-1583"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11997503"],"repository":["biostudies-literature"],"pubmed_title":["A BPTF-specific PROTAC degrader enhances NK cell-based cancer immunotherapy."],"pmcid":["PMC11997503"],"pubmed_authors":["Hao Q","Yan P","Ding C","Mei Y","Huang M","Chen H","Li Y","Liang H","Cao Z","Bai L","Wei H","Shen Y","Wang Y","Wang Z","He B","Jin J"],"additional_accession":[]},"is_claimable":false,"name":"A BPTF-specific PROTAC degrader enhances NK cell-based cancer immunotherapy.","description":"Natural killer (NK) cell-based immunotherapy shows promise in cancer treatment, but its efficacy remains limited, necessitating the development of novel strategies. In this study, we demonstrate that the epigenetic factor bromodomain PHD-finger containing transcription factor (BPTF) hinders hepatocellular carcinoma (HCC) recognition by NK cells through its PHD finger's interpretation of H3K4me3. We have generated a small-molecule proteolysis-targeting chimera (PROTAC) that selectively degrades human and murine BPTF. The degradation of BPTF using PROTACs directly enhances the abundance of natural cytotoxicity receptor ligands on HCC cells, facilitating their recognition by NK cells and thereby augmenting NK cell cytotoxicity against HCC both in vitro and in vivo. Through multidisciplinary t","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-06-01T12:58:29.265Z","creation":"2025-07-14T03:02:44.309Z"},"accession":"S-EPMC11997503","cross_references":{"pubmed":["39935175"],"doi":["10.1016/j.ymthe.2025.02.013"]}}