biostudies-literatureUnknown5(2)Escobar-Serna DP<h4>Background</h4>Noninvasive respiratory support (NRS) is standard in pediatric intensive care units (PICUs) for respiratory diseases, but its failure can lead to complications requiring invasive mechanical ventilation (IMV). This study aimed to identify risk factors for NRS failure in children with acute respiratory failure (ARF) in PICUs, and compare complications and outcomes between IMV-only and NRS failure patients.<h4>Methods</h4>We conducted a cohort study using data from the LARed Network prospective registry (April 2017-November 2022), in children under 18 years admitted to PICUs for ARF. Cases were divided into subgroups: those managed with IMV only, those who experienced NRS failure requiring IMV, those who received NRS successfully, and those who did not require NRS or IMV. EJournal of intensive medicine176-184https://www.ebi.ac.uk/biostudies/studies/S-EPMC11997567biostudies-literatureRisk factors and outcomes of pediatric non-invasive respiratory support failure in Latin America.PMC11997567Decia MGonzalez-Dambrauskas SCastro LJaramillo-Bustamante JCCaicedo Baez MCAlonso BBarajas-Romero JSHerrera HClavijo PDubra SReina CArdila IDussan BZamorano FCSerra ALopez Baron ELasso-Palomino RSilva JNannan-Toekoen AMartinez JVarela FMartinez LConcha SVarela JPeralta-Palmezano JJDiaz FCastro Zamorano FCarvajal Veas RCourtie CMenta SMonteverde-Fernandez NGiraldo Alzate CTamayo Munera CZemanate EJabornisky RSerra JACantiran KWolf RCaporal PVasquez-Hoyos PPerales Ibanez ELopez Alarcon YPAmadu JCarvajal CCantera APastorini JHerrera Salazar HDCasson Rodriguez NEscobar-Serna DPMadruga LLARed NetworkfalseRisk factors and outcomes of pediatric non-invasive respiratory support failure in Latin America.<h4>Background</h4>Noninvasive respiratory support (NRS) is standard in pediatric intensive care units (PICUs) for respiratory diseases, but its failure can lead to complications requiring invasive mechanical ventilation (IMV). This study aimed to identify risk factors for NRS failure in children with acute respiratory failure (ARF) in PICUs, and compare complications and outcomes between IMV-only and NRS failure patients.<h4>Methods</h4>We conducted a cohort study using data from the LARed Network prospective registry (April 2017-November 2022), in children under 18 years admitted to PICUs for ARF. Cases were divided into subgroups: those managed with IMV only, those who experienced NRS failure requiring IMV, those who received NRS successfully, and those who did not require NRS or IMV. E2025-01-01T00:00:00Z2025 Apr2025-07-14T03:02:53.576Z2025-07-14T03:02:53.576ZS-EPMC119975674024183410.1016/j.jointm.2024.09.001