biostudies-literatureMahboobi SSeven Oaks Chronic Disease Innovation CentreUniversity of ManitobaMitacsCanadian Institutes of Health ResearchCIHR751-767https://www.ebi.ac.uk/biostudies/studies/S-EPMC11997807biostudies-literatureUnknown40(4)<h4>Background</h4>Metabolic acidosis is a common complication of kidney disease and can result in further disease progression. Alkali therapy has been used to treat metabolic acidosis for decades. However, some concerns have been raised regarding its safety and long-term tolerability. Existing data suggest that dietary interventions can be beneficial in the management of chronic kidney disease (CKD). This systematic review and meta-analysis aims to summarize findings from studies comparing dietary interventions with placebo/usual care/no treatment in the management of metabolic acidosis in outpatient adults with CKD.<h4>Methods</h4>Medline, Embase, Cochrane Central, CINAHL and Web of Science Core Collection were searched from inception to June 2022. Our primary outcome measure was change Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal AssociationEffects of dietary interventions for metabolic acidosis in chronic kidney disease: a systematic review and meta-analysis.PMC11997807177969Mollard RAbou-Setta AMRahman TFerguson TRabbani RAskin NMacKay DMahboobi STangri NfalseEffects of dietary interventions for metabolic acidosis in chronic kidney disease: a systematic review and meta-analysis.<h4>Background</h4>Metabolic acidosis is a common complication of kidney disease and can result in further disease progression. Alkali therapy has been used to treat metabolic acidosis for decades. However, some concerns have been raised regarding its safety and long-term tolerability. Existing data suggest that dietary interventions can be beneficial in the management of chronic kidney disease (CKD). This systematic review and meta-analysis aims to summarize findings from studies comparing dietary interventions with placebo/usual care/no treatment in the management of metabolic acidosis in outpatient adults with CKD.<h4>Methods</h4>Medline, Embase, Cochrane Central, CINAHL and Web of Science Core Collection were searched from inception to June 2022. Our primary outcome measure was change 2025-01-01T00:00:00Z2025 Apr2025-07-10T03:08:29.054Z2025-07-10T03:08:29.054ZS-EPMC119978073927778010.1093/ndt/gfae200