biostudies-literatureCui JThe Veterans Administration Medical Center in MemphisUTHSCNatural Science Foundation of Heilongjiang Province, PR Chinae001872https://www.ebi.ac.uk/biostudies/studies/S-EPMC11997823biostudies-literatureUnknown10(1)<h4>Objective</h4>To compare the genetic characteristics of the normal control group to those of neovascular age-related macular degeneration (AMD) patients and to detect single-nucleotide polymorphisms (SNPs) related to the pathogenesis of neovascular AMD and the sensitivity to anti-VEGF drug, combercept.<h4>Method</h4>This is a prospective case-controlled study. A total of 104 neovascular AMD patients were treated with combercept and 106 normal subjects were served as the control group. SNPs associated with neovascular AMD and disease susceptibility and drug sensitivity were analysed.<h4>Results</h4>Significant differences existed between neovascular AMD patients and normal subjects among genotypes of the SNPs of two genes, ARMS2 (rs10490924 T) and HTRA 1 (rs11200638 A). The T alleles inBMJ open ophthalmologyGenotypes of SNPs of key genes regulate susceptibility and drug sensitivity to neovascular AMD in the human population.PMC11997823LH2019H063R073290110Ding HLi JZhao ACui JGu WYang BJablonski MMLu LXiu WLi ZLu HWang SJin CSun DLiu BSong XfalseGenotypes of SNPs of key genes regulate susceptibility and drug sensitivity to neovascular AMD in the human population.<h4>Objective</h4>To compare the genetic characteristics of the normal control group to those of neovascular age-related macular degeneration (AMD) patients and to detect single-nucleotide polymorphisms (SNPs) related to the pathogenesis of neovascular AMD and the sensitivity to anti-VEGF drug, combercept.<h4>Method</h4>This is a prospective case-controlled study. A total of 104 neovascular AMD patients were treated with combercept and 106 normal subjects were served as the control group. SNPs associated with neovascular AMD and disease susceptibility and drug sensitivity were analysed.<h4>Results</h4>Significant differences existed between neovascular AMD patients and normal subjects among genotypes of the SNPs of two genes, ARMS2 (rs10490924 T) and HTRA 1 (rs11200638 A). The T alleles in2025-01-01T00:00:00Z2025 Apr2026-06-01T20:42:26.881Z2025-07-03T03:06:55.78ZS-EPMC119978234022114410.1136/bmjophth-2024-001872