biostudies-literatureBalachandar RDepartment of Health Research, India1413https://www.ebi.ac.uk/biostudies/studies/S-EPMC11998342biostudies-literatureUnknown25(1)<h4>Background</h4>Air pollution is a significant public health concern, increasingly recognized for its association with adverse health outcomes including neurodegenerative and neuroinflammatory conditions. The present study aimed to characterize plasma levels of key biomarkers related to neurodegeneration and neuroinflammation among middle-aged to elderly adults living in areas designated as critically polluted.<h4>Methods</h4>A total of 202 adults, aged 41 to 60 years, residing in CPA (CEPI > 70) for over ten years were recruited in the study. The exposures of air pollutant were measured as per the established protocols by CPCB. The plasma levels of neurodegenerative markers (Aβ_(1-42), Total τ, α-Synuclein, BDNF and GFAP) were estimated using commercially available ultra-sensBMC public healthAssociation between chronic PM&lt;sub&gt;2.5&lt;/sub&gt; exposure and neurodegenerative biomarkers in adults from critically polluted area.PMC11998342Grant No. R.11013/01/2023-GIA/HRViramgami AChudasama BUpadhyay KSingh DPKulkarni NSivaperumal PBalachandar RfalseAssociation between chronic PM&lt;sub&gt;2.5&lt;/sub&gt; exposure and neurodegenerative biomarkers in adults from critically polluted area.<h4>Background</h4>Air pollution is a significant public health concern, increasingly recognized for its association with adverse health outcomes including neurodegenerative and neuroinflammatory conditions. The present study aimed to characterize plasma levels of key biomarkers related to neurodegeneration and neuroinflammation among middle-aged to elderly adults living in areas designated as critically polluted.<h4>Methods</h4>A total of 202 adults, aged 41 to 60 years, residing in CPA (CEPI > 70) for over ten years were recruited in the study. The exposures of air pollutant were measured as per the established protocols by CPCB. The plasma levels of neurodegenerative markers (Aβ_(1-42), Total τ, α-Synuclein, BDNF and GFAP) were estimated using commercially available ultra-sens2025-01-01T00:00:00Z2025 Apr2025-07-12T03:04:36.866Z2025-07-12T03:04:36.866ZS-EPMC119983424023485310.1186/s12889-025-22641-3