{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lu M"],"funding":["Guangdong Province Medical Science and Technology Research Foundation Project"],"pagination":["373"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11998445"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["<h4>Background</h4>Osteoarthritis (OA), a degenerative joint disease characterized by cartilage degradation and inflammation, lacks effective disease-modifying therapies. Quercetin, a bioactive flavonoid derived from Traditional Chinese Medicine, exhibits anti-inflammatory and chondroprotective properties but is limited by poor bioavailability. Mesenchymal stem cell-derived exosomes (MSC-Exos) offer a promising strategy for targeted drug delivery and cartilage regeneration.<h4>Methods</h4>Bone marrow-derived MSC exosomes (Que-Exo) were isolated after preconditioning with quercetin (1µM, 24 h). Their effects were evaluated in IL-1β-stimulated chondrocytes via RT-qPCR, Western blot, transcriptomics, and proteomics. An ACLT-induced OA mouse model received intra-articular injections of Que-Exo"],"journal":["Journal of orthopaedic surgery and research"],"pubmed_title":["Quercetin-primed MSC exosomes synergistically attenuate osteoarthritis progression."],"pmcid":["PMC11998445"],"funding_grant_id":["A2024661"],"pubmed_authors":["Lou A","Lu M","Fan W","Zhao L","Li S","Gao J","He L"],"additional_accession":[]},"is_claimable":false,"name":"Quercetin-primed MSC exosomes synergistically attenuate osteoarthritis progression.","description":"<h4>Background</h4>Osteoarthritis (OA), a degenerative joint disease characterized by cartilage degradation and inflammation, lacks effective disease-modifying therapies. Quercetin, a bioactive flavonoid derived from Traditional Chinese Medicine, exhibits anti-inflammatory and chondroprotective properties but is limited by poor bioavailability. Mesenchymal stem cell-derived exosomes (MSC-Exos) offer a promising strategy for targeted drug delivery and cartilage regeneration.<h4>Methods</h4>Bone marrow-derived MSC exosomes (Que-Exo) were isolated after preconditioning with quercetin (1µM, 24 h). Their effects were evaluated in IL-1β-stimulated chondrocytes via RT-qPCR, Western blot, transcriptomics, and proteomics. An ACLT-induced OA mouse model received intra-articular injections of Que-Exo","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-10T03:08:20.734Z","creation":"2025-07-10T03:08:20.734Z"},"accession":"S-EPMC11998445","cross_references":{"pubmed":["40229791"],"doi":["10.1186/s13018-025-05785-1"]}}