{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(4)"],"submitter":["Lerner A"],"funding":["Michael J. Fox Foundation for Parkinson's Research","Michael J. Fox Foundation for Parkinson&apos;s Research"],"pubmed_abstract":["<h4>Background</h4>Limited evidence exists regarding the meaningfulness of symptoms experienced in early Parkinson's disease (PD).<h4>Objectives</h4>To identify the most bothersome symptoms experienced by people with early PD, leveraging data from the Parkinson's Disease Patient Report of Problems (PD-PROP) questionnaire within the Fox Insight Study.<h4>Methods</h4>Individuals with a self-reported diagnosis of PD completed the PD-PROP questionnaire, reporting up to five most bothersome symptoms. Symptom types and frequencies were derived through a combination of human expertise and machine learning.<h4>Results</h4>Participants (N = 8536) were 0.9 years since diagnosis, predominantly white (96%), male (53.3%), and with an average age of 64.6 years. Top most bothersome motor symptoms were tr"],"journal":["Movement disorders clinical practice"],"pagination":["510-515"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11998684"],"repository":["biostudies-literature"],"pubmed_title":["Fox Insight: Most Bothersome Symptoms in Early-Stage Parkinson's Disease."],"pmcid":["PMC11998684"],"pubmed_authors":["Auinger P","Al-Rubayie R","Lerner A","Xiao Y","Adams JL","Marras C","Mammen JR","Tyo M"],"additional_accession":[]},"is_claimable":false,"name":"Fox Insight: Most Bothersome Symptoms in Early-Stage Parkinson's Disease.","description":"<h4>Background</h4>Limited evidence exists regarding the meaningfulness of symptoms experienced in early Parkinson's disease (PD).<h4>Objectives</h4>To identify the most bothersome symptoms experienced by people with early PD, leveraging data from the Parkinson's Disease Patient Report of Problems (PD-PROP) questionnaire within the Fox Insight Study.<h4>Methods</h4>Individuals with a self-reported diagnosis of PD completed the PD-PROP questionnaire, reporting up to five most bothersome symptoms. Symptom types and frequencies were derived through a combination of human expertise and machine learning.<h4>Results</h4>Participants (N = 8536) were 0.9 years since diagnosis, predominantly white (96%), male (53.3%), and with an average age of 64.6 years. Top most bothersome motor symptoms were tr","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-03T03:06:12.771Z","creation":"2025-07-03T03:06:12.771Z"},"accession":"S-EPMC11998684","cross_references":{"pubmed":["39754386"],"doi":["10.1002/mdc3.14321"]}}